Hemoglobinopathies
Chapter 84 Hemoglobinopathies M.A. Bender, Katie R. Nielsen Pearls • The pathophysiology of sickle cell disease is multifactorial, involving hemoglobin polymerization, oxidative damage to cell membrane proteins, white blood cell…
Pediatric Vascular Access and Centeses
Chapter 15 Pediatric Vascular Access and Centeses Stephen M. Schexnayder, Elizabeth A. Storm, Michael H. Stroud, Michele M. Moss, Ashley S. Ross, Richard T. Fiser, Muayyad Tailounie, Xiomara Garcia-Casal Pearls •…
Stroke and Intracerebral Hemorrhage
Chapter 63 Stroke and Intracerebral Hemorrhage Stuart Friess, Rebecca Ichord Pearls • Childhood stroke encompasses a wide spectrum of disease that can be categorized into three groups: arterial ischemic stroke,…
Thrombosis in Pediatric Intensive Care
Chapter 80 Thrombosis in Pediatric Intensive Care John Roy, Paul Monagle Pearls • Vascular access devices are the most common cause of thromboembolic disease in children, and every attempt should…
Status Epilepticus
Chapter 60 Status Epilepticus Cecil D. Hahn, Sam D. Shemie, Elizabeth J. Donner Pearls • Prolonged convulsive and nonconvulsive seizures cause neuronal injury by excitotoxic and hypoxic-ischemic mechanisms related to…
Renal Pharmacology
Chapter 70 Renal Pharmacology Douglas L. Blowey Pearls • For situations when the goal is the maintenance of a serum concentration close to the steady state level throughout the dosing…
Assessment of Cardiovascular Function
Chapter 22 Assessment of Cardiovascular Function Melvin C. Almodovar, Thomas J. Kulik, John R. Charpie Pearls • Cardiovascular assessment and monitoring in the pediatric intensive care unit requires careful integration…
Infectious Syndromes in the Pediatric Intensive Care Unit
Chapter 96 Infectious Syndromes in the Pediatric Intensive Care Unit Sonny Dhanani, Peter N. Cox Pearls • Because of the rapid progression of septicemia from meningococcus and variability of markers…
Molecular Foundations of Cellular Injury: Necrosis, Apoptosis, and Autophagy
Chapter 100 Molecular Foundations of Cellular Injury Necrosis, Apoptosis, and Autophagy Jared T. Muenzer, Craig M. Coopersmith Pearls • As an “accidental” form of death, necrosis is an uncontrolled process….
