Endotheliopathy
Chapter 101 Endotheliopathy Yves Ouellette, Jan A. Hazelzet Pearls • Because of their location, endothelial cells have the ability to interact with blood components, such as flow, soluble factors, and…
Hypertension in the Pediatric Intensive Care Unit
Chapter 73 Hypertension in the Pediatric Intensive Care Unit Ronald C. Sanders, Jr., Arno Zaritsky, Karen McNiece-Redwine Pearls • Systemic hypertension, an often underappreciated condition that is increasing at an…
Adverse Drug Reactions and Drug-Drug Interactions
Chapter 118 Adverse Drug Reactions and Drug-drug Interactions Wade W. Benton, Adam W. Brothers, Christa C. Jefferis Kirk, Gretchen A. Linggi Irby, Christopher M. Rubino Pearls • Although adverse drug…
Autoimmune Diseases: Diagnosis, Treatment, and Life-Threatening Complications
Chapter 98 Autoimmune Diseases Diagnosis, Treatment, and Life-Threatening Complications Jonna D. Clark, Helen M. Emery Pearls • Approximately 1 child in 250 has a rheumatologic disease. • Children may present…
Pediatric Neurologic Assessment and Monitoring
Chapter 55 Pediatric Neurologic Assessment and Monitoring Mark S. Wainwright Pearls • The examiner should focus both on localization of a neurologic deficit and identifying mechanism(s) of injury (or potential…
Neuroendocrine–Immune Mediator Coordination and Disarray in Critical Illness
Chapter 102 Neuroendocrine–Immune Mediator Coordination and Disarray in Critical Illness Kate Felmet, Joseph A. Carcillo Pearls • Activation of the hypothalamic-pituitary-adrenal axis is normal during stress. Lack of activation in…
Inborn Errors of Metabolism
Chapter 76 Inborn Errors of Metabolism Laurie Smith, Cary O. Harding Pearls • Unexpected and unexplained clinical deterioration in a previously healthy infant or child is an important clue to…
Shock States
Chapter 29 Shock States Lincoln S. Smith, Lynn J. Hernan Pearls • Shock is recognized by the features of tachycardia, tachypnea, and abnormalities of perfusion, as evidenced by skin perfusion,…
Acute Respiratory Distress Syndrome in Children
Chapter 52 Acute Respiratory Distress Syndrome in Children Stéphane Dauger, Philippe Durand, Etienne Javouey, Jean-Christophe Mercier Pearls • The incidence of acute lung injury and acute respiratory distress syndrome is…
Nutrient Metabolism and Nutrition Therapy During Critical Illness
Chapter 75 Nutrient Metabolism and Nutrition Therapy During Critical Illness Nilesh M. Mehta Pearls • Accurate assessment of nutritional status and provision of individually tailored optimal nutrition to the critically…
