Neural Blockade: Impact on Outcome
Neural Blockade: Impact on Outcome Christopher L. Wu Spencer S. Liu The importance of effective management of acute pain is clear from multiple studies documenting the undertreatment of pain and…
Modification of Metabolic Responses to Surgery by Neural Blockade
Modification of Metabolic Responses to Surgery by Neural Blockade Francesco Carli Thomas Schricker Catabolic Changes Induced by Surgical Stress The endocrine, metabolic, and inflammatory response to surgery make up the…
Local Anesthetic Systemic Toxicity
Local Anesthetic Systemic Toxicity Graeme A. McLeod John F. Butterworth IV J. A. W. Wildsmith Systemic toxicity is the term used to describe the clinical symptoms associated with extreme plasma…
Clinical Pharmacology of Local Anesthetics
Clinical Pharmacology of Local Anesthetics John F. Butterworth IV A review of the clinical pharmacology of local anesthetics must consider those factors that influence the usefulness and toxicity of the…
Properties, Absorption, and Disposition of Local Anesthetic Agents
Properties, Absorption, and Disposition of Local Anesthetic Agents Laurence E. Mather Geoffrey T. Tucker We dedicate this essay to the memory of our late friends and colleagues who contributed much…
Neural Physiology and Local Anesthetic Action
Neural Physiology and Local Anesthetic Action Gary R. Strichartz Els Pastijn Kenji Sugimoto Basic Physiology and Pharmacology Overview of the Neuron Local anesthetic drugs reversibly block conduction of nerve impulses…
The History of Regional Anesthesia
The History of Regional Anesthesia David L. Brown B. Raymond Fink The popularization of regional anesthesia was not possible until two events occurred. First, a local anesthetic was required, and…
Substance Abuse and Addiction
Substance Abuse and Addiction Arnold J. Berry Jerry S. Matsumura CASE SUMMARY A 36-year-old anesthesiologist was well liked by his anesthesiologist colleagues and was popular with patients. He arrived early…
Chemical Agents and Radiation Exposure
Chemical Agents and Radiation Exposure Paul Barach Ernesto Pretto Jr. CASE SUMMARY The New York City police stage a raid on a suspected terrorist chemical laboratory on the lower west…
Sleep and Fatigue
Sleep and Fatigue Timothy C. Flynn CASE SUMMARY Dr. W is a CA-2 resident in a university anesthesiology residency program. He has had a rough week. One of the other…
