The Perioperative Period—An Underutilized “Window-of-Opportunity” to Prevent Metastatic Disease The occurrence of metastatic disease is the leading cause of death in most patients with cancer. Accumulating evidence suggests that the…
Introduction As surgical and anesthetic techniques have evolved, perioperative mortality in complex cancer surgical interventions has decreased significantly. However, complications and associated morbidity remain a challenge not only for surgical…
Introduction At the intersection of oncology and cardiology, the field of cardio-oncology is growing primarily with the aim of recognizing, monitoring, and treating cardiovascular complications resulting from cancer-related treatments. With…
Introduction The management of cancer patients has evolved exponentially over time. At the start of the 19th century surgery was the only available modality to treat cancer, and surgery itself…
Introduction There have been rapid and substantial advances in cancer treatment with improved systemic therapies, including chemotherapy, hormone therapy, targeted therapy, and immunotherapy, as well as recent technologic advances in…
Introduction In spite of the evident cytoreductive, potentially curative advantages of surgery, there has long been a suspicion that resecting primary tumors carries an intrinsic, paradoxical risk with respect to…
Introduction Preoperative cancer therapies such as chemotherapy and radiation can have direct implications on perioperative management during cancer surgery. Chemotherapy is intended to prevent proliferation of malignant cells (cytostatic) and…
Introduction Since 1991, the global burden of disease has shifted from communicable to noncommunicable disease (NCDs), primarily due to prevention, mitigation, and treatment of infectious disease in low- and middle-income…
Introduction Cancer epidemiology provides the tools and methods to understand the cancer problem in any given population, from the local level up to the global level. Incidence, prevalence, and mortality…
Central Nervous System Infections Benjamin H. Schnapp Corlin Jewell THE CLINICAL CHALLENGE Infections of the central nervous system (CNS) can be rapidly fatal and require prompt intervention in order to…
