The Migraines: Introduction
The Migraines: Introduction Jes Olesen Peter J. Goadsby Migraine is an important and fascinating disorder. It is important because it is highly prevalent and severely disabling. The total sum of…
Human Models of the Headaches
Human Models of the Headaches Christina Kruuse Shazia Khan Afridi The unpredictable and episodic nature of many of the primary headaches introduces practical difficulties into research in this field, in…
Animal Models of Headache
Animal Models of Headache Andrew H. Ahn Peter J. Goadsby Animal models have been critical to our understanding of the neurobiology of primary headache syndromes, and entire volumes have been…
Triptan Signal Transduction
Triptan Signal Transduction Gareth W. John Peter J. Goadsby Seven serotonin (5-hydroxytryptamine; 5-HT)1B/1D receptor agonists derived from tryptamine, commonly termed triptans, are now in routine clinical use: almotriptan, eletriptan, frovatriptan,…
Ion Channels Relevant to Pain
Ion Channels Relevant to Pain Kevin Shields Arn van den Maagdenberg ION CHANNELS AND PAIN A wide variety of voltage- and ligand-gated ion channels are needed for the generation and…
Other Molecules Involved in Pain Transmission
Other Molecules Involved in Pain Transmission Anthony Dickenson The aim of this chapter is to bring together data on a number of other molecules that have not been covered in…
Prostanoids and Other Inflammatory Mediators
Prostanoids and Other Inflammatory Mediators Christian Waeber Introduced by Bayer in 1899, acetylsalicylic acid (aspirin [ASA]) is today the most extensively prescribed analgesic, antipyretic, and anti-inflammatory agent, with 120 billion…
Sex Hormones
Sex Hormones Nancy E. J. Berman Michael M. Behbehani Millions of women suffer migraine headaches around the time of their menstrual cycles, a phenomenon known as menstrual migraine. Clinical studies…
Calcitonin Gene-Related Peptide and Other Peptides
Calcitonin Gene-Related Peptide and Other Peptides Susan Brain Lars Edvinsson Vasoactive peptides can be either stored or synthesized de novo before release from a range of tissues in the brain…
Nitric Oxide
Nitric Oxide Andrew A. Parsons The importance of nitric oxide (NO) in modulation of biological pathways has been known for over 20 years. The seminal studies by Furchgott and Zwadzki…
