Liberal Transfusion Strategy in the Perioperative Period
CaO2 is the sum of oxygen bound to hemoglobin and oxygen dissolved into the plasma and is calculated as follows: where 1.34 is the amount of oxygen bound by each…
Tranexamic Acid to Reduce Perioperative Mortality
Clinical summary Drug/technique Indications Cautions Side effects Dose Tranexamic acid Prophylaxis for surgery that confers a high risk of bleeding or intervention for massive refractory intraoperative/postoperative bleeding Absolute contraindications: allergy/hypersensitivity…
Reducing Mortality in the Perioperative Period: A Continuous Update
Systematic[sb] AND (surgery[tiab] OR surgic*[tiab] OR operation*[tiab]) AND ((myocardial AND infarction) OR (death* OR survival OR mortality OR prognosis)) AND (prevent* OR reducti* OR reduci*) (Surgery[tiab] OR surgic*[tiab] OR operation*[tiab])…
Randomized Evidence of Mortality Reduction Not Confirmed in Most Recent Works: A Methodological Problem
© Springer International Publishing AG 2017Giovanni Landoni, Laura Ruggeri and Alberto Zangrillo (eds.)Reducing Mortality in the Perioperative Period10.1007/978-3-319-46696-5_19 19. Randomized Evidence of Mortality Reduction Not Confirmed in Most Recent Works: A Methodological Problem Laura Ruggeri1 and Martina Baiardo Redaelli1…
Role of Insulin in Reducing Mortality in the Perioperative Period
Route of administration Insulin Onset of action Peak of action Effective duration of action Subcutaneous Regular human insulin 30–60 min 2–3 h 4–6 h ” Rapid-acting analogues (aspart, lispro, glulisine)…
Aprotinin: Pharmacological Benefits and Safety
Meta-analysis Year of publication No. of patients No. of studies OR (CI 95 %) OR (CI 95 %) OR (CI 95 %) – – – – Aprotinin vs. tranexamic acid…
Reducing Mortality in the Perioperative Period: Remote Ischemic Preconditioning
© Springer International Publishing AG 2017Giovanni Landoni, Laura Ruggeri and Alberto Zangrillo (eds.)Reducing Mortality in the Perioperative Period10.1007/978-3-319-46696-5_15 15. Reducing Mortality in the Perioperative Period: Remote Ischemic Preconditioning Dana Y. Fuhrman1 and John A. Kellum1 (1) Department of Critical Care…
Statins and Perioperative Mortality
Clinical summary Indications Cautions Side effects Dose Notes Hypercholesterolemia Primary and secondary prevention of cardiovascular disease Muscle-related (myalgia, myopathy, myonecrosis, rhabdomyolysis) in 1.5–5 % of the patients Isolated increase in…
Perioperative Supplemental Oxygen to Reduce Perioperative Mortality
Fig. 10.1 The “oxygen cascade” with partial pressure of oxygen (PO 2 ) falling from ambient air to the mitochondria. Factors affecting oxygenation at different levels are shown at the top…
Chlorhexidine Oral Rinse to Reduce Perioperative Mortality
Fig. 12.1 Structure of chlorhexidine (1:6-di[4-chlorophenyldiguanido]-hexane). The two biguanide groups (green arrows) are protonated at physiological pH (as shown in the yellow box) so that the molecule is positively charged Chlorhexidine…
