IN ANESTHESIA

Aug 28, 2016 by in ANESTHESIA Comments Off on IN ANESTHESIA

•  In pediatric patients a 20–24 gauge needle may be used for the first cannulation and then exchanged with a larger gauge over a guidewire •  Proceed as described in…

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AUTONOMIC, AND CARDIOVASCULAR DRUGS

Aug 28, 2016 by in ANESTHESIA Comments Off on AUTONOMIC, AND CARDIOVASCULAR DRUGS

ADRENERGIC AGONISTS General comments: Act on α, β, or dopaminergic receptors (see the table below). May cause tachycardia, hypertension, arrhythmias, myocardial ischemia, and tissue necrosis with extravasation (administer centrally, treat…

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ANESTHETICS

Aug 28, 2016 by in ANESTHESIA Comments Off on ANESTHETICS

PHARMACODYNAMICS •  Ionization best correlates with onset of action. LAs exist in free equilibrium in both charged (ionized) and neutral (non-ionized) forms: • The ionized form binds to the receptor…

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BLOCKING DRUGS

Aug 28, 2016 by in ANESTHESIA Comments Off on BLOCKING DRUGS

•  Clinical Considerations •  Indications: Bolus dosing used for rapid sequence induction when aspiration is a risk (i.e., full stomach, trauma, diabetes mellitus, hiatal hernia, obesity, pregnancy); infusion useful in…

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ANESTHETICS

Aug 28, 2016 by in ANESTHESIA Comments Off on ANESTHETICS

GENERAL PRINCIPLES •  Lipophilic drugs produce rapid induction of general anesthesia •  Most IV anesthetics exert effect through activation or augmentation of postsynaptic GABAA receptors (↑ chloride influx → hyperpolarization…

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