(1) Department of Anesthesiology, Tulane Medical Center, New Orleans, LA, USA (2) Department of Anesthesiology, Louisiana State University, New Orleans, LA, USA Michael Yarborough Email: myarboro@tulane.edu Introduction Drug Class…
Fig. 1.1 The relationship among the pharmacokinetic processes of absorption, distribution, metabolism, and excretion with the central, peripheral, and site of action compartments Upon closer examination, PK includes even the…
Chemical Structure 29.1 Gabapentin Chemical Structure 29.2 Phenytoin Chemical Structure 29.3 Carbamazepine Chemical Structure 29.4 Lamotrigine Chemical Structure 29.5 Levetiracetam Chemical Structure 29.6 Topiramate Chemical Structure 29.7 Ethosuximide References 1….
Fig. 52.1 The chemical structures of gantacurium (a) and CW002 (b). The chlorine (a, red circle) substituted at the olefinic double bond of gantacurium was designed to accelerate the inactivation…
Fig. 48.1 Acetyl-CoA pathway to its end points Drug Classes Statins Statins are the gold standard for lowering cholesterol. This class of medications was originally created through extraction from a…
Opioid Metabolic pathway Major metabolites Analgesic activity Adverse effect Morphine UGTB27 M3G N Nausea, neuroexcitatory effects M6G Y Prolonged duration especially with renal insufficiency Fentanyl CYP3A4 Norfentanyl N n/a Hydromorphone…
Severity Characteristics Therapies Intermittent – mild Daytime symptoms ≤2×/week Short-acting β2 agonist Nocturnal awakenings ≤2×/month Use SABA ≤2×/week FEV1 or PEF ≥80 % predicted Asymptomatic between exacerbations 0 –1 exacerbations/year requiring…
Chemical Structure 23.1 Amphetamine (Adderall) Chemical Structure 23.2 Modafinil (Provigil) Chemical Structure 23.3 Armodafinil (Nuvigil) Chemical Structure 23.4 Caffeine Chemical Structure 23.5 Methylphenidate (Ritalin) Chemical Structure 23.6 Atomoxetine (Strattera) HCl…
Because the AT-III level recovery varies, thus 20 min after infusion of initial dose, recheck AT-III level and recalculate the additional dose necessary to correct AT-III deficiency. Then it is…
Fig. 31.1 Four phases of cell division (Source: Brunton et al. [3]. Copyright © McGraw Hill Companies, Inc) Antimetabolites (S-Phase) Antimetabolite drugs are also referred to as nucleic acid synthesis…
