Fig. 23.1 a Propofol TCI set at 3 μg/ml, b MCI propofol infusion regimen, designed to give a plasma concentration of 3 μg/ml: 1 mg/kg bolus, 10 mg/kg/h, reduced to 8 mg/kg/h at 10 min, reduced…

Fig. 10.1 Time course of plasma propofol concentrations arising from three different dosing schemes. All three time courses show the predicted plasma concentration of propofol administered at 8 mg/kg/h for 60 min…

  2. Adjusted body weight (kg) [28]: Was derived to scale doses in the obese. It uses the ideal weight (IBW) and to a varying degree the amount of weight…

Fig. 8.1 The volume of distribution accounts for the dilution of drug when it is first injected into the body Fig. 8.2 Clearance is the flow of blood or plasma…

Bedford and Leeds recommendations Recent considerations • Careful risk-benefit analysis for surgery on elderly patients • Frailty assessment • Consideration of the risk of postoperative cognitive dysfunction • No routine…

  Minimal sedation Moderate sedation Deep sedation General anaesthesia Responsiveness Normal response to verbal stimulation Purposeful response to verbal or tactile stimulation Purposeful response following repeated or painful stimulation Unrousable…

Drugs Species Elimination half-life Volume of distribution Total systemic clearance Comments References Propofol Dogs 322 min 6.5 L/kg 50.1 mg/kg/min No premed, no co-infusion Beagle dogs [5]a 486.2 min 3.38 L/kg 34.4 mg/kg/min Premedication medetomidine 10 μg/kg,…

Used on a data set [1] for propofol this becomes However for most practitioners this equation, which describes only one of several drugs used during a typical anaesthetic, has little practical…

Fig. 15.1 Diagram of the postsynaptic nicotinic acetylcholine receptor at the neuromuscular junction with the five subunits. Each subunit contains four transmembrane domains labelled M1 to M4. Reproduced from Naguib…

Reports Reports of AAGA had to be of procedures in which the patient expected to be unconscious First reports (irrespective of when the AAGA occurred) collected over 12 months Reports…