Spreading Depression Martin Lauritzen Richard P. Kraig The characteristic development of sensory disturbances during migraine auras suggests that the underlying mechanism is a disturbance of the neocortex, probably spreading depression…
Migraine Comorbidity Kathleen Ries Merikangas Nancy C. D. Low Birthe Krogh Rasmussen Comorbidity, introduced by Feinstein, refers to the presence of any additional coexisting ailment in a patient with a…
Epidemiology of Migraine Birthe Krogh Rasmussen During the last decade studies of the epidemiology of migraine have clarified our understanding of the scope and distribution of the public health problem…
The Migraines: Introduction Jes Olesen Peter J. Goadsby Migraine is an important and fascinating disorder. It is important because it is highly prevalent and severely disabling. The total sum of…
Human Models of the Headaches Christina Kruuse Shazia Khan Afridi The unpredictable and episodic nature of many of the primary headaches introduces practical difficulties into research in this field, in…
Animal Models of Headache Andrew H. Ahn Peter J. Goadsby Animal models have been critical to our understanding of the neurobiology of primary headache syndromes, and entire volumes have been…
Triptan Signal Transduction Gareth W. John Peter J. Goadsby Seven serotonin (5-hydroxytryptamine; 5-HT)1B/1D receptor agonists derived from tryptamine, commonly termed triptans, are now in routine clinical use: almotriptan, eletriptan, frovatriptan,…
Ion Channels Relevant to Pain Kevin Shields Arn van den Maagdenberg ION CHANNELS AND PAIN A wide variety of voltage- and ligand-gated ion channels are needed for the generation and…
Other Molecules Involved in Pain Transmission Anthony Dickenson The aim of this chapter is to bring together data on a number of other molecules that have not been covered in…
Prostanoids and Other Inflammatory Mediators Christian Waeber Introduced by Bayer in 1899, acetylsalicylic acid (aspirin [ASA]) is today the most extensively prescribed analgesic, antipyretic, and anti-inflammatory agent, with 120 billion…
