Triptan Signal Transduction Gareth W. John Peter J. Goadsby Seven serotonin (5-hydroxytryptamine; 5-HT)1B/1D receptor agonists derived from tryptamine, commonly termed triptans, are now in routine clinical use: almotriptan, eletriptan, frovatriptan,…
Ion Channels Relevant to Pain Kevin Shields Arn van den Maagdenberg ION CHANNELS AND PAIN A wide variety of voltage- and ligand-gated ion channels are needed for the generation and…
Other Molecules Involved in Pain Transmission Anthony Dickenson The aim of this chapter is to bring together data on a number of other molecules that have not been covered in…
Prostanoids and Other Inflammatory Mediators Christian Waeber Introduced by Bayer in 1899, acetylsalicylic acid (aspirin [ASA]) is today the most extensively prescribed analgesic, antipyretic, and anti-inflammatory agent, with 120 billion…
Sex Hormones Nancy E. J. Berman Michael M. Behbehani Millions of women suffer migraine headaches around the time of their menstrual cycles, a phenomenon known as menstrual migraine. Clinical studies…
Calcitonin Gene-Related Peptide and Other Peptides Susan Brain Lars Edvinsson Vasoactive peptides can be either stored or synthesized de novo before release from a range of tissues in the brain…
Nitric Oxide Andrew A. Parsons The importance of nitric oxide (NO) in modulation of biological pathways has been known for over 20 years. The seminal studies by Furchgott and Zwadzki…
Serotonin and Other Biogenic Amines Christian Waeber Biogenic amines such as serotonin, norepinephrine, histamine, and dopamine are naturally occurring biologically active amines synthesized from three different amino acids. Histidine is…
Imaging Pain Irene Tracey Martin Ingvar OBJECTIFYING THE PAIN EXPERIENCE Over the past 15 years, we have witnessed a shift in our understanding of pain processing in humans from the…
Peripheral and Central Sensitization Related to Headaches Rami Burstein Dan Levy Moshe Jakubowski Clifford J. Woolf CLINICAL MANIFESTATIONS OF PERIPHERAL AND CENTRAL SENSITIZATION Among the common symptoms of peripheral sensitization…
