Are Anti-inflammatory Therapies in ARDS Effective?
The acute respiratory distress syndrome (ARDS) is a syndrome of acute lung injury (ALI) caused by direct or indirect damage to the lung parenchyma. It is characterized clinically by acute…
Do Nonventilatory Strategies for Acute Respiratory Distress Syndrome Work?
The inflammatory injury suffered by the alveolar epithelium–endothelium complex provides multiple potential therapeutic targets. The inflammatory process could be inhibited at any stage from the genome to inflammatory signaling to…
Inhaled Vasodilators in ARDS: Do They Make a Difference?
Inhaled vasodilators have a compelling physiologic rationale in the management of critically ill patients with acute respiratory distress syndrome (ARDS). A 20-year accumulation of rigorous research has helped to clarify…
Is Permissive Hypercapnia Useful in ARDS?
Traditional approaches to the carbon dioxide (CO 2 ) management of adults with acute respiratory failure have focused on the potential for hypercapnia to exert deleterious effects. Support for this…
Is Pulmonary Hypertension Important in ARDS? Should We Treat It?
In this chapter, we systematically examine the evidence linking acute respiratory distress syndrome (ARDS) with pulmonary hypertension, the implications of pulmonary hypertension and consequent right ventricular failure for patient outcomes,…
Do Patient Positioning in General and Prone Positioning in Particular Make a Difference in ARDS?
Changes in posture and position invariably accompany activity in healthy adults, with likely salutary effects on physiology. Similar changes in position during illness have important effects on cardiovascular and pulmonary…
What Is the Best Mechanical Ventilation Strategy in ARDS?
The term acute respiratory distress syndrome (ARDS) describes acute inflammatory lung injury caused by a wide variety of insults, resulting in severe hypoxemic respiratory failure. ARDS has been recognized as…
What Are the Pathologic and Pathophysiologic Changes That Accompany Acute Lung Injury and ARDS?
Diverse inciting events lead to acute respiratory distress syndrome (ARDS), including pneumonia, sepsis, pancreatitis, and trauma. These are generally divided into events that directly injure the lung (e.g., pneumonia) or…
What Is the Clinical Definition of ARDS?
Acute respiratory distress syndrome (ARDS) is an acute, diffuse, inflammatory injury to the alveolar epithelium and pulmonary vascular endothelium that leads to nonhydrostatic pulmonary edema and impaired pulmonary gas exchange….
Are Computerized Algorithms Useful in Managing the Critically Ill Patient?
In mathematics and computer science, an algorithm is a step-by-step procedure for solving a problem. Algorithms are used for calculation, data processing, and automated reasoning. Expressed as a finite list…
