Key Wordsage, body habitus, clearance, interactions, patient characteristics, pharmacodynamics, pharmacokinetics, volumes of distribution Key Points ▪ Pharmacokinetics describes the relationship between drug dose and drug concentration in plasma or…
Key Points ▪ The normal physiology of neuronal function, receptors, and ion channels is altered by persistent pain. ▪ Because of the large number of sources and manifestation of chronic…
Key Points ▪ The history and physical examination most accurately predict the risks of anesthesia and the likelihood of required changes in monitoring or therapy. ▪ For diabetic patients, end-organ…
▪ Identify the type of cardiovascular implantable electronic device (CIED) (pacemaker, transvenous defibrillator, subcutaneous defibrillator), as well as the generator manufacturer and model of the CIED. ▪ Contact the physician…
Key WordsCharcot-Marie-Tooth Disease, Dantrolene, Guillain-Barre Syndrome, Malignant Hyperthermia, Multiple Sclerosis, Muscular Dystrophy, Ryanodine Key Points ▪ Malignant hyperthermia (MH) is a pharmacogenetic disorder inherited primarily in an autosomal dominant…
Key Points ▪ The introduction of thiopental into clinical practice in 1934 marked the beginning of modern intravenous (IV) anesthesia. Today, IV anesthetics are used for induction and maintenance of…
Key Points ▪ Two different populations of nicotinic acetylcholine receptors exist at the mammalian neuromuscular junction. In the adult, the nicotinic acetylcholine receptor at the postsynaptic (muscular) membrane is composed…
Key Points ▪ The alveolar anesthetic concentration (F A ) or partial pressure (P alv ) is important because it is the driving force determining anesthetic uptake into blood and…
Key Points ▪ Herbal medication use has increased dramatically in the overall population and particularly in preoperative patients. ▪ Patients might not volunteer information unless they are queried specifically about…
