Abstract The institution of CPB has profound effects on the plasma concentration, distribution and elimination of drugs. The major factors responsible for this are haemodilution, altered plasma protein binding, altered…
Abstract Heart disease is a common congenital abnormality, affecting 5–9 per 1,000 newborns. Successful evolution of treatment strategies has led to a significant reduction in the number of deaths from…
Abstract This chapter highlights key aspects of management and potential complications in children following cardiac surgery. Critical to this is an understanding of diagnosis, physiology, appropriate physiological targets and multidisciplinary…
Abstract Historically, the cardiac catheterization laboratory has been used for blood sampling, contrast-enhanced imaging and intravascular pressure measurement to provide diagnostic and prognostic information and to guide surgical intervention. In…
Abstract Congenital heart disease (CHD) occurs in approximately 8:1,000 live births and may be associated with recognizable syndromes or chromosomal abnormalities in 25% of cases. Abnormalities are often complex, affecting…
Abstract As the indications for these devices has widened, the prevalence of permanent pacemakers (PPMs) and ICDs has increased. The complexity of these devices makes them susceptible to perioperative interference…
Abstract Pulmonary vascular surgery comprises emergency procedures such as pulmonary embolectomy and post-traumatic repair, and elective procedures such as palliation of PHT, pulmonary thromboendarterectomy (PTE), tumour resection and the Ross…
Abstract Mechanical circulatory support (MCS) can be used in a setting of either acute or chronic heart failure in selected patients refractory to medical management, to augment the failing circulation…
Abstract Thoracic aortic disease is often difficult to detect and may remain asymptomatic until presenting acutely, which in turn is associated with high rates of complications, morbidity and mortality. This…
Abstract The first successful human-to-human heart transplant was performed by Christiaan Barnard in 1967 but the initial outcomes were poor. The introduction of ciclosporin resulted in a significant improvement in…
