Individual Differences in Pain: The Roles of Gender, Ethnicity, and Genetics Roger B. Fillingim The experience of pain is characterized by tremendous interindividual variability.1 Indeed, similar injuries, disease states, or…
Psychological Aspects of Pain Dennis C. Turk Kimberly Shawn Swanson Hilary D. Wilson Advances in the knowledge of the neurophysiology of pain have resulted in the development of new pharmacologic…
Supraspinal Mechanisms of Pain and Nociception Michael Hauck Ürgen Lorenz The preceding chapters addressed the peripheral and spinal mechanisms of nociceptive processing. Neither normal nor pathologic pain can be understood…
Modulation of Spinal Nociceptive Processing Timothy J. Ness Alan Randich Jennifer J. Deberry The preceding chapter addressed the neuroanatomy and neurochemistry of neurons located within the spinal cord that process…
Substrates of Spinal Cord Nociceptive Processing Jennifer J. Deberry Alan Randich Timothy J. Ness The spinal cord and brainstem nuclei are home to second-order neurons, the first step of central…
Peripheral Pain Mechanisms and Nociceptor Sensitization Michael S. Gold Pain has been categorized by duration (acute vs. chronic), location (superficial or deep; cutaneous, bone/joint, muscle, or viscera), and cause or…
Intellectual Milestones in Our Understanding and Treatment of Pain G. F. Gebhart In order to treat something we first must learn to recognize it. —Sir William Osler1 Through the ages,…
Pain Terms and Taxonomies of Pain Dennis C. Turk Akiko Okifuji The inherent subjectivity of pain presents a fundamental impediment to increased understanding of its mechanisms and control. The language…
6 Medication-Related Problems Case 6.1 Medication Error Case A long time ago, a 2 8/12-year-old girl, 14 kg, was scheduled for full-body scintigraphy because of suspected osteomyelitis in the presence…
7 Pre-existing Conditions Case 7.1 Malignant Hyperthermia Case Several decades ago, a 6-year-old girl, weighing 22 kg, was scheduled for adenotomy. With maternal presence, smooth anaesthesia induction was achieved with…
