Chapter 79 Pharmacokinetics, pharmacodynamics and drug monitoring in critical illness Richard N. Upton, John A. Myburgh, Raymond G. Morris Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism and…
Chapter 14 Monitoring oxygenation Thomas John Morgan, Balasubramanian Venkatesh THE ROLES OF OXYGEN IN AEROBIC ORGANISMS Oxygen has several vital physiological roles: 1 Bioenergetics. Aerobic mitochondrial respiration accounts for 90%…
Chapter 16 Acute cardiac syndromes, investigations and interventions Brad Power Cardiovascular disease (CVD) accounts for 35–40%1 of deaths in western industrialised society, with coronary artery disease (CAD) being responsible for…
Chapter 19 Cardiac pacing and implantable cardioverter/defibrillators Karl D. Donovan, Bernard EF. Hockings Cardiac pacing has rapidly evolved since its introduction by Zoll in 1952.1 The technological knowledge gained in…
Chapter 33 Non-invasive ventilation Graeme Duke, Andrew D. Bersten Non-invasive ventilation (NIV) is a valuable therapeutic option in the management of acute and chronic respiratory failure – for some diagnoses…
Chapter 77 Blast injury and gunshot wounds pathophysiology and principles of management Stephen Brett Widespread terrorist outrages in the recent past have once again served to emphasise that unpredictable events…
Chapter 12 Haemodynamic monitoring David J. Sturgess, Thomas John Morgan Haemodynamics is the study of blood flow. Haemodynamic monitoring therefore refers to the monitoring of blood flow through the cardiovascular…
Chapter 67 Severe head injury John A. Myburgh Despite improvements in resuscitation and vital organ support, the management of patients with traumatic brain injury in the intensive care unit (ICU)…
Chapter 82 Inotropes and vasopressors John A. Myburgh The pharmacological support of the failing circulation is a fundamental part of critical care. The principal aim of these drugs is to…
Chapter 69 Chest injuries Ubbo F. Wiersema CHEST INJURIES The majority of chest injuries in Australasia result from blunt trauma due to motor vehicle crashes. Less frequent causes include falls…
