Macrolides
123 Macrolides David T. Bearden The macrolide class of antibiotics is based on the structure of erythromycin, the prototype natural macrolide isolated from Streptomyces erythreus.1 Commonly the term macrolide is…
Acute Parenchymal Disease in Pediatric Patients
72 Acute Parenchymal Disease in Pediatric Patients Kathleen M. Ventre, John H. Arnold Pulmonary parenchymal processes in children that the intensive care clinician may encounter include common and uncommon diseases…
Critical Care Nutrition
94 Critical Care Nutrition Juan B. Ochoa, Daren K. Heyland, Stephen A. McClave The overall efficacy of nutritional support, the need to start nutritional therapy (NT) in the first place,…
Methamphetamine, Ecstasy, and Other Street Drugs
189 Methamphetamine, Ecstasy, and Other Street Drugs John R. Richards, Robert W. Derlet History The first documented synthesis of methamphetamine, utilizing ephedrine as a substrate, occurred in 1918 in Japan….
Invasive Cardiac Procedures
77 Invasive Cardiac Procedures Stéphane Manzo-Silberman, Olivier Varenne Percutaneous Transluminal Coronary Angioplasty Chronic ischemic heart disease is usually due to obstruction of the coronary arteries by atherosclerosis. It is the…
Hematologic Malignancies in the Intensive Care Unit
154 Hematologic Malignancies in the Intensive Care Unit Delphine Moreau, Élie Azoulay, Benoit Schlemmer With the rapid improvement in chemotherapy, targeted therapy, and supportive care of hematology patients, almost all…
Vascular Catheter–Related Infections
128 Vascular Catheter–Related Infections Scott Norwood, Alan D. Cook Catheter-related bloodstream infection (CRBSI) is the third leading device-related infection among U.S. hospitals and ambulatory surgical centers in the United States…
Fluoroquinolones
122 Fluoroquinolones Douglas N. Fish The fluoroquinolones are synthetically derived, broad-spectrum antibacterial agents designed for both intravenous (IV) and oral administration. Since the introduction of ciprofloxacin in the late 1980s,…
Heart-Lung Interactions
47 Heart-Lung Interactions Michael R. Pinsky, Hernando Gomez Ventilation can profoundly alter cardiovascular function. The boundaries of the cardiovascular unit’s responsiveness are defined by both cardiovascular and pulmonary factors. These…
Acute Lung Injury and Acute Respiratory Distress Syndrome
58 Acute Lung Injury and Acute Respiratory Distress Syndrome Julie A. Bastarache, Lorraine B. Ware, Gordon R. Bernard Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common…
