Fig. 12.1 Structure of chlorhexidine (1:6-di[4-chlorophenyldiguanido]-hexane). The two biguanide groups (green arrows) are protonated at physiological pH (as shown in the yellow box) so that the molecule is positively charged Chlorhexidine…
Authors, Year, Type of study Studies, Number of participants Type of patients Monitoring devices Conclusions Poeze et al. [9], Meta-analysis 30 RCTs, 5,733 pts High-risk surgery, trauma, acute medical sepsis…
Meta-analysis Year of publication Number of patients Number of studies OR (CI 95 %) OR (CI 95 %) OR (CI 95 %) – – – – Aprotinin versus tranexamic acid Aprotinin versus aminocaproic…
Search strategy for meta-analyses of RCTs Systematic [sb.] AND (surgery [tiab] OR surgical* [tiab] OR operation* [tiab]) AND [(myocardial AND infarction) OR (death* OR survival OR mortality OR prognosis)] AND…
Route of administration Insulin Onset of action Peak of action Effective duration of action Subcutaneous Regular human insulin 30–60 min 2–3 h 4–6 h Subcutaneous Rapid-acting analogues (aspart, lispro, glulisine) 15 min 30–90 min 3–4 h…
Target PPM, antimicrobials, manoeuvres Total daily dosea <5 years 5–12 years >12 years Parenteral antimicrobials – – – Cefotaxime, mg 150/kg 200/kg 4,000 Enteral antimicrobials – – – Oropharynx – – – AGNB:…
Clinical summary Indications Cautions Complications Notes High-risk coronary artery bypass grafting Aortic regurgitation Aggravation of aortic regurgitation Imaging is required to confirm correct aortic placement of this device Severe myocardial…
Fig. 2.1 Consensus conference process 2.1 Step 1. Evidence Collection and Analysis The aim of this conference was to identify all the interventions influencing mortality in the perioperative period, including only…
Study Setting No. of patients Blood products End points Results (%) p van de Watering [5] Cardiac surgery 914 BCD-RBC vs. LR (pre-storage) vs. LR (poststorage) 60-day mortality 7.8 vs….
Study N Drug Onset and duration Surgery Results Mangano/1966 200 Atenolol 50–100 mg Before induction—7-d postop Noncardiac surgery Reduced mortality at 6 m (0 vs. 8 %, p < 0.001), at 1 y (3 vs. 14 %, p = 0.005),…
