Fig. 4.1
Summary of patients undergoing elective non-cardiac surgery in Australian and New Zealand Hospitals in 2010–11 [1]. Patients aged over 65 years are over-represented compared to other age groups and reflects an ageing population (Reproduced with permission from Australian Bureau of Statistics)
Preoperative clinics were introduced to reduce the incidence of late surgical cancellation from inadequate patient preparation and to reduce the requirement of day-before admission, thus improving perioperative efficiency. The American Heart Association recommends that the goals of pre-operative cardiac evaluation include provision of medical clearance for surgery, accurate assessment and management of cardiac disease and collaborating with the perioperative anaesthesia team in management that might improve cardiac outcome [8]. Traditional clinical assessment includes history taking, physical examination (clinical assessment), and ordering of indicated tests. Principal cardiac risk factors of adverse postoperative cardiac outcome include left ventricular dysfunction [9–11], ischaemic heart disease, aortic stenosis [12, 13] and pulmonary hypertension [14]. Clinical assessment for these conditions is unreliable, especially if symptoms are masked by exercise limitations from non-cardiac disease (such as painful joints or peripheral vascular disease), unreliable patient history, or incomplete medical records. Detection of a murmur with auscultation is common, but diagnosis or exclusion of aortic stenosis and pulmonary hypertension is unreliable without transthoracic echocardiography [15–17]. Investigation for ischaemic heart disease also requires preoperative testing that may not be available before surgery [8]. As a result, anaesthetists are frequently faced with the dilemma of deferring surgery to obtain pre-operative tests and cardiology assessment in patients with suspected cardiac disease, or allowing non-cardiac surgery to proceed without adequate investigation.
4.2 Transthoracic Echocardiography
4.2.1 Comprehensive (Traditional) Transthoracic Echocardiography
The ability to non-invasively assess left and right systolic and diastolic ventricular function, valvular disease and pulmonary hypertension makes transthoracic echocardiography (TTE) a commonly performed preoperative investigation. Exclusion of left ventricular failure or severe aortic stenosis may assist in clearance for surgery and, on the other hand, if diagnosed, then may prompt referral to a cardiologist for an opinion on perioperative risk, or to reduce risk with either medical or surgical treatment prior to surgery. The current British, European and American cardiology societal recommendations for TTE before elective non-cardiac surgery are listed in Table 4.2 [18–20]. Although TTE may identify structural evidence of ischaemic heart disease, such as regional wall motion abnormality and scar, it has a low sensitivity and specificity for ischaemic heart disease, for which exercise testing is recommended [8]. Guidelines also discourage repeat TTE with no intervening change in clinical status within 12 months [18].
Table 4.1
Current societal recommendations for indications of transthoracic echocardiography before non-cardiac surgery
Society | Indication |
---|---|
British Society of Echocardiography [18] | Documented IHD with reduced functional capacity (<4 metabolic equivalents) |
Unexplained shortness of breath in the absence of clinical signs of heart failure | |
Abnormal electrocardiogram (ECG) and/or chest X-ray | |
Murmur in the presence of cardiac or respiratory symptoms | |
Murmur in an asymptomatic individual in whom clinical features or other investigation suggest severe structural heart disease | |
European Society of Cardiology and Anaesthesiology [20] | Established or suspected heart failure in patients scheduled for intermediate or high-risk surgery |
Established or suspected valvular disease in patients scheduled for intermediate or high-risk surgery | |
American Society of Echocardiography [19] | Stress TTE to investigate for suspected IHD in patients with reduced functional capacity presenting for high-risk vascular procedures |
Table 4.2
Cardiac pathology identified with transthoracic echocardiography associated with cardiac complications after non-cardiac surgery
Author | Cardiac pathology | Postoperative cardiac risk | |||
---|---|---|---|---|---|
Rohde [9] | Myocardial infarction Odds ratio (95 % CI) | Cardiogenic pulmonary oedema Odds ratio (95 % CI) | Major cardiac complications Odds ratio (95 % CI) | ||
Reduced LV systolic function | 2.8 (1.1–7.0) | 3.2 (1.4–7.0) | 2.4 (1.3–4.5) | ||
LV hypertrophy | 3.1 (1.1–8.3) | 1.5 (0.6–3.8) | 2.2 (1.1–4.3) | ||
Mitral regurgitation | 1 (0.4–4.2) | 2.4 (1.0–5.6) | 2.3 (1.2–4.6) | ||
Aortic stenosis | 3.8 (0.5–32) | 6.4 (1.3–32) | 6.3 (1.5–26) | ||
Halm [11] | Ischaemic outcomes | Congestive heart failure | All cardiac outcomes | ||
Ejection fraction <40 % | 2.7 (0.7–11) | 3.0 (1.2–7.4) | 3.5 (1.8–6.7) | ||
LV wall motion abnormality | 1.3 (0.5–3.3) | 1.3 (0.5–3.3) | 1.6 (1.3–2.1) | ||
LV hypertrophy | 0.5 (0.1–3.7) | 1.2 (0.5–3.3) | 1.2 (0.7–2.0) | ||
Park [10] | Myocardial infarction | Congestive heart failure | Cardiovascular death | ||
Ejection fraction <50 % | 1.6 (0.9–2.8) | 2.3 (1.7–3.1) | 8.7 (2.6–26.6) | ||
LV wall motion abnormality | 1.5 (0.9–2.4) | 1.7 (1.2–2.2) | 1.7 (1.3–2.2) | ||
Flu [25] | 30-day cardiovascular morbidity Odds ratio (95 % CI) | Long-term cardiovascular morbidity Odds ratio (95 % CI) | |||
Reduced LV systolic function | 2.3 (1.4–3.6) | 4.6 (2.4–8.5) | |||
Reduced LV diastolic function | 1.8 (1.1–2.9) | 3.0 (1.5–6.0) | |||
Kertai [12] O’Keefe [13] | Perioperative/postoperative cardiac events/cardiac deaths | ||||
Aortic stenosis | Aortic stenosis 14 % compared with controls 2 %, relative risk 5.2 (1.6–17) | ||||
Aortic stenosis | Aortic stenosis 14 % compared with controls 0 % | ||||
Cowie [26] | Adverse cardiac events % | Positive predictive value % (95 % CI) | Sensitivity | Specificity | |
LV/RV dysfunction | 58 | 58 (39–75) | 48 | 92 | |
Aortic stenosis | 88 | 14 (3–35) | 8 | 89 | |
Pulmonary hypertension | 63 | 64 (47–79) | 64 | 92 | |
Ramakrishna [14] | Pulmonary hypertension | Short-term morbid event occurred in 42 %, early death in 7 % |
Despite frequent use, the current evidence for the use of preoperative TTE for risk estimation is not strong (Table 4.2) and improvements in outcome after elective non-cardiac surgery has not yet been subjected to testing with an adequately powered randomised controlled trial. However, in a large retrospective cohort study of 264,823 patients aged over 40 years presenting for intermediate to high-risk non-cardiac surgery, preoperative echocardiography was not associated with improved survival or shorter hospital stay [21]. The only other report is a small retrospective cohort study that demonstrated a twofold 12-month survival advantage in elderly patients undergoing hip fracture surgery who received preoperative TTE compared with controls [22].
Access to TTE, traditionally performed by cardiology or radiology departments, is variable and the waiting times in many centres may be prolonged due to high demand and reduced availability [23], potentially interfering with surgical work flow [24]. The expansion in use of TTE coupled with persistent economic pressure has lead to a reduction in availability of TTE for preoperative testing in the USA.
4.2.2 Focused Transthoracic Echocardiography
Over the last 10 years there has been a rapid uptake in the clinical use of TTE by emergency and critical care physicians and anaesthetists to guide decision-making in real time, or at the ‘point-of-care’ [27]. This has occurred due to improved portability, availability and affordability of equipment as well as the realisation that accuracy of clinical assessment can be substantially improved with only limited training and views [28]. Haemodynamic state and cardiac pathology can be diagnosed very quickly, even during a cardiac arrest [29], guiding important decision-making during initial assessment, rather than waiting for a third party to perform the investigation, essentially representing ‘ultrasound assisted examination’ [2].
The use of focused TTE has been demonstrated to improve clinical assessment and alter important treatment decisions in the order of 50 % of patients either experiencing or at risk of persistent haemodynamic instability in intensive care [30], emergency department [31] and perioperative settings [17, 26], including the preoperative clinic [2] (Fig. 4.2). In 2012, ‘point-of-care’ physician-performed TTE was defined as focused cardiac ultrasound (FCU) and endorsed in a position statement from the American Society of Echocardiography [32] and in another position statement on preoperative assessment before non-cardiac surgery from the European Society of Cardiology and Anaesthesiology [20].
Fig. 4.2
Focused transthoracic echocardiography may be performed at the initial anaesthetist’s assessment of patients presenting for noncardiac surgery, enabling convenient, faster and more accurate diagnosis of cardiac disease
In a prospective observational study of 100 patients presenting for assessment by the anaesthetist in the preoperative clinic for non-minor elective noncardiac surgery, the treating anaesthetist’s plan was recorded before and after focused TTE was performed by an independent operator. The treating anaesthetists deemed 80 patients to have suspected cardiac disease (Table 4.3) and 20 patients who were not at increased cardiac risk, other than being aged over 65 years. Focused TTE identified at least moderately severe cardiac ventricular or valvular dysfunction in 36 % of the high-risk patients (where TTE was indicated as shown in Table 4.3) and 10 % of the low risk patients (overall 32 %), resulting in a change in management decisions in 54 % (Fig. 4.3). Not only did the TTE result in changes in decision to proceed or postpone surgery without subjecting the patient to postponement of surgery for a repeat appointment, but also altered the anaesthetic technique (regional and general anaesthetic), invasive haemodynamic monitoring and treatment and use of postoperative high dependency care. When a clinically important haemodynamic or valvular abnormality (or worsening of known abnormality) was detected on TTE (e.g. the 11 patients with aortic stenosis), the anaesthetist was alerted to increased cardiac risk, who stepped up their level of care (in 24 %). On the other hand, a clinically unimportant finding or normal TTE had the effect of reassuring the anaesthetist, leading to a reduced requirement for further investigation, invasive haemodynamic monitoring and high dependency postoperative care (step down in care in 30 %). Furthermore, the overall impact of the TTE findings was to improve hospital efficiency by reducing delays to surgery and referrals for further medical opinions, suggesting a resulting cost-savings to the hospital [33].
Table 4.3
Indications for preoperative focused TTE in 100 patients who received focused transthoracic echocardiography in the preoperative clinic
Indication | Percentage (%) |
---|---|
Not indicated – Age >65 years, no cardiac disease suspected | 20 |
Indicated – cardiac disease suspected | 80 |
Signs and/or symptoms of cardiac disease | 26 |
Known cardiac disease but suspected deterioration | 15 |
Murmur on auscultation (not previously documented) | 15 |
Abnormal cardiac investigation (not echo) | 8 |
Unable to exercise and cardiac disease suspected | 9 |
Pulmonary hypertension and/or right ventricular failure suspected | 5 |
Previous peri-operative cardiac complication(s) | 2 |
Fig. 4.3
The influence on anaesthetist decision-making on preoperative evaluation after the addition of focused transthoracic echocardiography to standard clinical assessment of patients aged over 65 years or with suspected cardiac disease (Reproduced with permission from Wiley, from Canty et al. [2]) CVP central venous pressure monitoring, HDU high dependency unit, PHT pulmonary hypertension, RHF right heart failure, TOE transoesophageal echocardiography
Another finding was that focused TTE led to a significant change in management in patients in whom the only identified risk factor was age greater than 65 years, raising the question whether focused TTE should be routine in this population. This was also found in a similar study performed in patients undergoing emergency non-cardiac surgery [17].
The findings from this study not only confirmed that routine anaesthetist-performed TTE was feasible and could be used to assist in decisions for suitability of patients for surgery, but it also influenced the anaesthesia and postoperative medical care in an attempt to reduce poor postoperative outcome, addressing the suggested criteria set by the American Heart Association in preoperative evaluation. However the study was not designed to assess the influence of TTE on postoperative outcome and this question remains unanswered. Another important limitation is lack of consensus and resultant variability in management of specific cardiac disorders and anaesthesia techniques. Despite this, the overall effect of routine focused TTE is earlier detection of patients at increased cardiac risk allowing time for appropriate management decisions. In this study, focused TTE identified clinically significant cardiac pathology in 36 % of patients with suspected cardiac disease (Table 4.3), a similar finding by Faris et al. [34] who reported 27.6 % of patients using comprehensive TTE when used as per published recommendations from the American Society of Echocardiography [35].
4.2.3 Specific Cardiac Pathology Identified with Echocardiography
4.2.3.1 Left Ventricular Function
Patients with a history of congestive heart failure (CHF) have a higher incidence of postoperative CHF and death (Table 4.2), and preoperative TTE is indicated in patients who have suspected CHF or worsening of known CHF (Table 4.1). This is also the case with asymptomatic left ventricular diastolic failure, found in 21 % of patients presenting for vascular surgery [25]. However, ischaemic complications are not clearly correlated with preoperative CHF, for which stress testing is recommended [8]. Preoperative identification of CHF enables optimisation with medical therapy, such as with diuretics and vasodilators, as well as guides perioperative care, including minimising haemodynamic stress from less invasive surgery and anaesthesia and tighter perioperative fluid balance and monitoring for cardiac complications.