The History of Anesthesia in Mexico, the Caribbean Islands, and Central America



Fig. 26.1
Pedro Van der Linden (standing), Surgeon in Chief to the Mexican Army, after performing his first amputation in a patient anesthetized with ether. Two soldiers hold the wounded soldier, perhaps still asleep (second from left), and a third soldier holds the amputated limb. This daguerreotype copy was taken at the Battle of Cerro Gordo, 18 April 1847 from reference 3 with permission from the publisher. (Courtesy of Gaceta Médica de México)



Pablo Martinez del Rio introduced ether into Mexico in 1848 (for general and obstetrical surgery), and then introduced chloroform in 1849. Years later (1878), he reported his experiences with chloroform in obstetric anesthesia [5]. He supported the use of chloroform anesthesia during general surgery, but advised against it in obstetrics in order to avoid massive blood loss and death, particularly in uterine dystocia. He suggested that it should be used only to achieve analgesia: “More than one mishap could have been avoided if the parturient would not have been under the influence of chloroform.”

Fernando López Sánchez, a surgeon and ophthalmologist in the armed forces, was trained in Paris. In 1886, he returned to Mexico and began using cocaine topically, for superficial ocular surgery. During the 1890s, to avoid the use of general anesthesia with chloroform, he described a technique in which he injected 1% cocaine around the eyeball to perform enucleations and other major procedures [6].

In July 1900, in Oaxaca, Mexico, following a description published by Theodore Tuffier in 1899, Ramon Pardo used 15 mg cocaine hydrochloride injected at the 5th lumbar interspace to produce spinal anesthesia for amputation of a leg. He used a Pravaz syringe and a 9 cm long needle designed by Tuffier to obtain cerebrospinal fluid and inject the cocaine, achieving excellent anesthesia without side effects [79].

Bandera reported [10] that in the early 1900s, the most common anesthetic techniques used by surgeons in Mexico were local/topical anesthesia with cocaine for ophthalmic surgery, ethyl chloride for incision and drainage of superficial abscesses, and chloroform or spinal anesthesia for general surgery. Ether was reserved for very sick patients only. The consensus among surgeons was that chloroform was a potent and “toxic” anesthetic that could kill the patient instantly, or in the immediate postoperative period, by producing profound depression leading to coma, anuria and death [11,12]. They considered that ether was a “ safer” anesthetic, and was better tolerated than chloroform by sick patients [12]. Induction was said to be more pleasant with chloroform, which explains its continued use. However, they concluded that “it is about time to discard chloroform, but unfortunately we are immersed in a tight routine of spinal and chloroform for all patients….” Ether was available.

To deliver chloroform, a gauze mask was used. A similar mask could be used for ether, or alternatively, a Fowler, Clover or Allis’s mask or inhaler (metal frame, covered with leather and containing a folded cloth to absorb the ether) [13]. A dropper (Fig. 26.2) was also required, together with a mouth opener, and forceps to hold the tongue in case of a sudden respiratory arrest. Caffeine and strychnine were used to treat cardiac depression manifested by bradycardia and “cerebral anemia” (loss of consciousness or profound depression), and adrenalin was used for accidents occurring during spinal anesthesia. A report of anesthetics given at the Hospital General de Mexico, shows the greater popularity of spinal anesthesia (Table 26.1) and its lower mortality (p<0.0001– chi square analysis) [12].



A978-1-4614-8441-7_26_Fig2_HTML.jpg


Fig. 26.2
Examples of the metal frames that were used to support the gauze onto which ether and chloroform were dropped. Two examples of the drip bottles used to deliver ether or chloroform also are shown. (Courtesy of Museo del Palacio de Medicina y de la Dirección General del Patrimonio Universitario, UNAM (DGPU/1239/2013), Mexico City, Mexico)




Table 26.1
Anesthetics Given at the Hospital General de Mexico, 1905-mid-1920s



















































 
Number of Cases

%

Spinal anesthesia with cocaine

9452

100.00

Spinals completed with chloroform

687

7.27

Failed spinals

661

6.99

Deaths related to spinal anesthesia

6

0.06

General anesthesia with chloroform

8372

100.00

Cardiac arrests during chloroform

18

0.19

Deaths related to chloroform

19

0.22

Mixed anesthetics

401
 

General anesthesia with ether

307
 

Anesthesia with ethyl chloride

80
 

In addition, the author compared the mortality occurring in the US at the time, with the same anesthetics: chloroform 1 death/2,500, ether 1/16,000 and nitrous oxide 1/200,000 cases [12].

In 1908, Louis Ombrédanne described an anesthetic apparatus for the simple delivery of ether anesthesia (Fig. 26.3), popularizing its use [14]. Nitrous oxide anesthesia, and carbon dioxide absorbers were introduced in the 1910s and 1920s respectively [10].



A978-1-4614-8441-7_26_Fig3_HTML.jpg


Fig. 26.3
The ether inhaler designed by Louis Ombrédanne in 1908. (Courtesy of the Wood Library-Museum of Anesthesiology, Park Ridge, IL)

In 1932, Federico Vollbrechthausen, a trainee from the Mayo Clinic, came to Mexico to practice anesthesia, bringing ethylene, cyclopropane, and a closed circuit apparatus for their administration. He brought hexobarbital (later replaced by thiopental) for intravenous use, and procaine for spinal and local anesthesia. In 1941, an American thoracic surgeon, Leo Eloesser, and his anesthesiologist colleague William Neff, a former pupil of Ralph Waters, came to Mexico City to demonstrate thoracic surgery and anesthesia at the Hospital for Tuberculosis Diseases. Neff used tracheal intubation and controlled ventilation with a closed circuit apparatus [15]. Jorge Terrazas and Martin Maquívar then employed it, reporting in 1944 on the first “19 cases of anesthesia with controlled ventilation for thoracic anesthesia” [16]. The 1940s also saw the introduction of curare, and the monitoring of vital signs. Cyclopropane became as popular as ether due to its capacity to produce a rapid induction, its potency, and the wide margin between anesthetic and lethal concentrations.

In 1956, Michael Johnstone came to Mexico to demonstrate the use of halothane, which then largely replaced ether and cyclopropane over the next decade [17] A lesser proportion of the flammable anesthetics were replaced by methoxyflurane and enflurane. However, neither achieved great popularity. Their use was discontinued in 1980, with the arrival of isoflurane. Halothane continued in use until the 1990s, when Melman and Lozano introduced desflurane and sevoflurane into Mexico [18,19]. The latter agents are those currently in use.



Regional Anesthesia in Mexico


As noted earlier, Ramón Pardo introduced spinal anesthesia in 1900 [7,8]. Cocaine, amylocaine (Stovaine), and subsequently procaine hydrochloride were the commonly used local anesthetics, until displaced by tetracaíne and lidocaine. In 1923, Leopoldo Escobar gave the first caudal anesthesia to a patient suffering from sciatica. In 1939, in Monterrey, Mexico, Rodolfo Rodriguez performed the first lumbar epidural block.

For almost two decades, obstetricians/gynecologists administered anesthesia for obstetrics, either intravenously with a combination of meperidine 50–100 mg plus promethazine 50 mg and promazine 25 mg, or as a spinal anesthetic with tetracaíne. In 1938, surgeon Isidro Espinosa de los Reyes, used a catheter to achieve a continuous caudal epidural [20]. Two other surgeons (Mateos Fournier and Jose Rabago) [21] later introduced Robert Hingson’s and Waldo Edwards’s continuous caudal analgesia technique for obstetrics In 1956, anesthesiologists Vicente García Olivera [22], Guillermo Vasconcelos [23], Fernando Rodriguez de la Fuente [24], and Carlos Martínez Redding [25] took obstetric anesthesia from the hands of the surgeons at the hospitals of the Social Security Institute. They replaced spinal (because of hypotension) and caudal (because of catheter contamination) anesthesia with lumbar epidural anesthesia. This practice, with its benefits for the parturient and the newborn, rapidly spread to other hospitals. Currently, unless contraindicated, lumbar epidural block is applied in 95–98% of obstetric cases (Marrón M. Personal Communication. Ob/Gyn Anesthesiologist. Former Director Division of Postgrade and Continuous Education in Health. Secretaría de Salud, Mexico).

Epidural or subarachnoid anesthesia had not been used in children until Melman, Marrufo, and Penuelas, working at the Children’s Hospital in Mexico City (Hospital Infantil de México), compared the effects of subarachnoid versus epidural block, and from studies in cadavers and patients, Melman, Tandazo and Arenas, determined the doses needed to reach different dermatomes [26,27]. Surgeons initially opposed the use of these techniques, but the benefits quickly overcame their reservations. Currently, at the Children’s Hospital, central neuraxial anesthesia is used in about 50% of cases and results in the earlier discharge of patients [28]. Epidural anesthesia in children is nowadays used throughout Mexico, having displaced spinal anesthesia because of the longer postoperative analgesia possible with continuous epidural anesthesia.

In 1945, Vicente García Olivera went to New York to train under E Rovenstine at the Bellevue Hospital in New York who had founded a Pain Clinic in 1936. García Olivera later attended a course at the Veterans Administration Pain Clinic in McKinney, Texas [29]. He was an enthusiast in regional anesthesia, in all its modalities, central neuraxial, sympathetic, and peripheral blocks. In 1948, he created the first center for pain treatment at the London Clinic, in Mexico City (Hospital Clínica Londres). In 1975 he organized the first Pain Clinic at the Hospital General de México. which in 1992 became the National Center for Training in Pain Therapy (Centro Nacional de Capacitación en Clínica y Terapia del Dolor) [29].


The Mexican Society of Anesthesiology


In 1934, led by physicians Emilio Varela, Federico Vollbrenthausen, Juan Morquecho, Francisco Fierro and Benjamín Bandera, the Surgical Society of the Hospital Juarez in Mexico City founded the Society of Anesthetists of Mexico (Sociedad de Anestesistas de Mexico), the first anesthesia society created in Latin America. In 1948, the Society changed its name to the Mexican Society of Anesthesiologists (MSA), appointing members from other Mexican states [30].

In 1946, the MSA organized its first National Congress of Anesthesia, holding subsequent congresses every two years until 1974, when annual meetings were instituted. The MSA participated in the founding of societies of anesthesia in other states of Mexico, such as the Society of Anesthesiology of Jalisco in 1948, and the Society of Anesthesiologists of Monterrey, in 1954. In 1960, the societies assembled into a Federation of Mexican Societies of Anesthesia (FSARM). In 1955, the MSA participated as Mexico’s representative in the creation of the World Federation of Societies of Anesthesia (WFSA), and in 1962, in the Confederation of Latin American Societies of Anesthesia (CLASA). The MSA was appointed by the FSARM to be the main organizer of the 6th World Congress of Anesthesiology held in Mexico City in 1976. In 1994 the MSA changed its name to Colegio Mexicano de Anestesiología (COMEXANE) to more effectively represent its members before government authorities [31]. The former Federation of Societies (FSARM) is now called FMCA, AC (Federación Mexicana de Colegios de Anestesia, Asociación Civil). The Mexican College of Anesthesiology, in Mexico City, has 1500 members. The total number of anesthesiologists in Mexico is approximately 12,000, with 8,000 board certified as of September 2011.


Goals of the Mexican College of Anesthesiology (Formerly Society)




1.

To promote information about anesthesia. Aspects of the specialty are presented and discussed in monthly meetings. An Annual Meeting has been held with the participation of foreign and national speakers and professors since 1974.

 

2.

To promote research in anesthesia. To further this aim, the “Benjamín Bandera Foundation” was created in 1976. A Trust Fund established with the profits from the 6th World Congress of Anesthesia held in 1976 in Mexico City, was used to support the Foundation.

 

3.

To improve clinical care: anesthesia courses and workshops are conducted in different hospitals.

 

4.

To promote the countrywide development of societies of anesthesia.

 

In 1960, the Society supported the founding of the Federation of Mexican Societies of Anesthesia (FSARM). State societies of anesthesia, one or two for each state for a total of 60, combined to form FSARM [32]. The Society (now College), also supported the founding and organization of societies of different anesthesia subspecialties including pediatrics (SAP), obstetrics and gynecology (SMAGO), cardiothoracic anesthesia, and pain [33].


Residency Programs in Anesthesia


The establishment of several major medical institutions in Mexico City in the 1940s facilitated the development of anesthesia training programs. They included the Children’s Hospital in 1943, the National Institute of Cardiology in 1944, the Institute for Medical Sciences and Nutritional Diseases (Instituto Nacional de Ciencias Médicas y Nutrición) in 1946, and the Hospitals in the Mexican Institute for Social Security. The training programs were supported initially by the Mexican Society of Anesthesiologists (MSA) and later by the National University of Mexico (UNAM) and the Mexican Board of Anesthesiology.

In 1957, the MSA organized the first postgraduate course in anesthesia, appointing members of the Society as professors. The 24-month course was held in Mexico City at the General Hospital (Hospital General de México). Physicians taking the course and training received a monthly salary enabling them to leave their former practice and devote their entire time to anesthesia. The MSA continued to organize these courses until 1962. The anesthesiologists thus trained, and others trained in Canada and the US, initiated residency programs in anesthesia in several Mexican hospitals.

In 1966, the MSA and the National University initiated a two-year residency program [19,20]. A 3 year program was established in 1986 at the National University. This was achieved through the co-operation of the National Committee for Postgraduate Education, the Ministry of Health, the MSA’s Academic Committee in Anesthesia and the Mexican Federation of Societies of Anesthesia [21,22]. Acceptance for subspecialty training in pediatrics, neuro-anesthesia, cardiothoracic anesthesia, critical care, obstetrics/gynecology, or pain, currently requires that the appointee be certified by the Mexican Board of Anesthesia. Subspecialty credentialing demands a further 2 years of training in the designated subspecialty [33].


Mexican Board of Anesthesia


In 1974, members of the MSA, as advised by the National Academy of Medicine, created the Mexican Board of Anesthesia (Consejo Mexicano de Anestesiología; Archivo del Consejo Mexicano de Anestesiología 1974). Candidates were certified after 3 years of a residency program in one of the hospitals appointed as training hospitals, and after taking a written and oral examination. The Board was also responsible for approving and certifying the congresses and the courses held as part of the continuing medical education programs. The Board also determined recertification of all anesthesiologists every 5 years, granting the permit to continue to practice anesthesia. This process of accreditation and certification by the Anesthesia Board, was equivalent to the process that was carried out by the 47 specialty councils recognized by the National Committee for Medical Specialties (CONACEM).


Practice of Anesthesia


As in many parts of the world, surgeons were the first to administer anesthesia in Mexico. However, the shortage of physicians also dictated that nurses and technicians perform these tasks. Nurses and technicians received one year tutorial courses from trained anesthesiologists; these courses ceased in the early 1970s. Finally, after a long campaign conducted by Mexican anesthesiologists, the authorities and politicians in Mexico became convinced that anesthesia was a medical specialty, best administered by trained physicians. This was incorporated into Mexican law in 1998.1


Revista Mexicana de Anestesiología (Mexican Journal of Anesthesiology)


The founding members of the MSA published the first anesthesia articles as a supplement called “Anesthesia” in the “Journal of Surgery of the Hospital Juarez” from 1936 until 1939. Subsequent anesthesia articles were published in “Medicina” [10,31].

In July 1951, the first issue of Revista Mexicana de Anestesiologia (RMA) was published, with Benjamín Bandera as the first director and Vicente García Olivera as editor [10]. It was the second anesthesia journal (after Argentina’s) published in Latin America. Since its first publication, it has appeared every three months. It is abstracted or indexed by standard databases (16 databases including Scopus, but not Medline), and is distributed to all members of the Mexican Society. It is the main anesthesia journal published in Mexico, and is the official publication of the Mexican College of Anesthesiology, (COMEXANE). The journal promotes the publication of clinical and basic research in anesthesia and perioperative medicine, critical care, and pain. The Editorial Board accepts papers submitted for publication by Mexican and Spanish speaking Latin American anesthesiologists.

Since 2006, the Colegio Mexicano de Anestesiología also edits quarterly, the Mexican Clinics of Anesthesia, with Raul Carrillo Esper as the current editor-in-chief of both publications [34]. Another Mexican journal “Anestesia”, edited by the Mexican Federation (FMCAAC), has had an irregular publication schedule; currently it is published online every 4 months.

Globalization has permitted the rapid spread of knowledge and technology. In Mexico the quality of medicine may now be comparable to that practiced in first world countries. The US Joint Commission on Health Care Accreditation, (JAHCO) has accredited several hospitals in Mexico City and other states in Mexico, as having standards comparable to those in the US (e.g., the American British Cowdray Medical Center).



Anesthesia in Caribbean Islands and Central America


Anesthesia developed unevenly in Caribbean Islands and Central American countries in the several decades after Morton’s historic demonstration in 1846 (Tables 26.2 and26.3). This remarkable observation makes one marvel at the diverse conditions that led to a virtual absence of anesthesia in some countries until the last quarter of the nineteenth century, whereas other countries benefited from anesthesia within a year of its discovery. Of course, some of the information may overestimate how long it took to incorporate anesthesia into practice, since for some drugs, little data are available, while for others (ether-chloroform) we have sufficient information. Although a good explanation for the late arrival of anesthesia in many countries is lacking, socio-cultural and economic factors probably underlie the variability in the delay, but as Sherlock Holmes said: “it is a capital mistake to theorize before one has data.”




Table 26.2
Initial Use of Anesthetics in Mexico, Caribbean Islands and Central America












































































Country

Ether

Chloroform

Nitrous Oxide

Curare

Cocaine

Spinal

Epidural

Mexico

1847

1849

1910s

1942

1890s

1899

1923

Cuba

1847

1848

1918

1950s

1886

1900

1937

Dominican Republic

1861

1861

1930s?

1953


1916

1957

Guatemala

1847

1859

1930?

1950

1901

1901

1935

Honduras

1900s

1900s

1960s

1960s


1950s

1966

El Salvador

1899

1870

1937

1949

1886

1902

1941

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Mar 21, 2017 | Posted by in ANESTHESIA | Comments Off on The History of Anesthesia in Mexico, the Caribbean Islands, and Central America

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