Role of Inhalational Anesthetic Agents in Reducing Perioperative Mortality


Clinical summary

Drug

Indications

Cautions

Side effects

Dosage

Notes

Inhalational agents

Myocardial protection during general anesthesia for cardiac and noncardiac surgeries

Myocardial protection is dose and duration of inhalational anesthetic agent dependent

Common side effects of inhalational agents such as hypotension, myocardial depression, arrhythmias, and effects on other solid organs

Unclear at the moment

Myocardial protection, decrease in infarct size, and reduction in mortality during cardiac surgery have been well documented. However, the benefit during noncardiac surgery has not yet been convincingly shown





References



1.

Landoni G, Rodseth RN, Santini F et al (2012) Randomized evidence for reduction of perioperative mortality. J Cardiothorac Vasc Anesth 26:764–772PubMedCrossRef


2.

Landoni G, Biondi-Zoccai GG, Zangrillo A et al (2007) Desflurane and sevoflurane in cardiac surgery: a meta-analysis of randomized clinical trials. J Cardiothorac Vasc Anesth 21:502–511PubMedCrossRef


3.

Fleisher LA, Beckman JA, Brown KA et al (2007) ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: executive summary. A report of the American college of cardiology/American heart association task force on practice guidelines (Writing committee to revise the 2002 guidelines on perioperative cardiovascular evaluation for noncardiac surgery). J Am Coll Cardiol 50:1707–1732PubMedCrossRef


4.

Mattheussen M, Rusy BF, Van Aken H et al (1993) Recovery of function and adenosine triphosphate metabolism following myocardial ischemia induced in the presence of volatile anesthetics. Anesth Analg 76:69–75PubMedCrossRef


5.

Boutros A, Wang J, Capuano C (1997) Isoflurane and halothane increase adenosine triphosphate preservation, but do not provide additive recovery of function after ischemia, in preconditioned rat hearts. Anesthesiology 86:109–117PubMedCrossRef

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Apr 6, 2017 | Posted by in CRITICAL CARE | Comments Off on Role of Inhalational Anesthetic Agents in Reducing Perioperative Mortality

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