CHAPTER 48 RISK OF SERIOUS BACTERIAL INFECTION IN FEBRILE INFANTS WITH RSV

Risk of Serious Bacterial Infection in Young Febrile Infants With Respiratory Syncytial Virus Infections

Levine DA, Platt SL, Dayan PS, et al. Pediatrics. 2004;113(6):1728–1734

BACKGROUND

Fever can be the only marker of impending septicemia and a key cause of infant mortality. It is challenging to identify neonates at high risk of sepsis from those with more benign etiologies of fever. Although this challenge had been partially addressed by the Rochester, Philadelphia, and Boston criteria, these diagnostic protocols require invasive testing. At the time of this study, it was unclear whether having a diagnosed viral illness, such as Respiratory syncytial virus (RSV), lowered the risk for having a serious bacterial infection (SBI).

OBJECTIVES

To determine the risk of SBI in febrile infants with RSV.

METHODS

Prospective, multicenter, cross-sectional study at eight pediatric EDs in the United States between 1998 and 2001.

Patients

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