Cardiothoracic and Vascular Anesthesia

Colchicine prevents early postoperative pericardial and pleural effusions

Imazio M, Brucato A, Rovere ME, et al (Maria Vittoria Hosp, Torino, Italy; Ospedali Riuniti, Bergamo, Italy; Ospedale Mauriziano, Torino, Italy; et al) Am Heart J 162:527-532.e1, 2011^§

Abstract

Background

No preventive pharmacologic strategies have been proven efficacious for the prevention of postoperative effusions after cardiac surgery. Colchicine is safe and efficacious for the prevention of pericarditis. On this basis, we realized a substudy of the COPPS trial to assess the efficacy and safety of colchicine for the prevention of postoperative pericardial and pleural effusions.

Methods

The COPPS is a multicenter, double-blind, randomized trial, where 360 consecutive patients (mean age 65.7 ± 12.3 years, 66% men), 180 in each treatment arm, were randomized on the third postoperative day to receive placebo or colchicine for 1 month (1.0 mg twice daily for the first day, followed by a maintenance dose of 0.5 mg twice daily in patients ≥70 kg, and halved doses for patients <70 kg). The incidence of postoperative effusions was evaluated in each study group.

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