Pediatric sepsis is distinct from adult sepsis in its definitions, clinical presentations, and management. Recognition of pediatric sepsis is complicated by the various pediatric-specific comorbidities that contribute to its mortality and the age- and development-specific vital sign and clinical parameters that obscure its recognition. This article outlines the clinical presentation and management of sepsis in neonates, infants, and children, and highlights some key populations who require specialized care.
Key points
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Age-specific vital signs and development-specific clinical parameters complicate the early recognition of pediatric sepsis.
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Early goal-directed therapy in pediatric sepsis differs from adult guidelines in the selection of inotropes and the recommendation to start vasoactive medications peripherally while securing central access.
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Intraosseous needles and umbilical catheters are pediatric-specific modalities for providing sepsis treatment.
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