(1)
Department of Anaesthesia, Royal Free Hospital, London, UK
Neuropathies can be divided into whether they affect large-diameter fibres or small-diameter fibres.
Painful neuropathies involving large fibres | Hypothyroidism |
Painful neuropathies involving small fibres | Diabetes mellitus Amyloidosis |
Painful neuropathies involving nonselective fibres | Alcoholism |
30.1 Hypothyroidism
Untreated thyroid insufficiency leads to axonal degeneration with demyelination. It presents with pain in the feet and difficulty in walking. Biopsies show decreased myelinated fibre densities with selective loss of Aβ fibres.
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