Cardiothoracic and Vascular Anesthesia

Effects of Donor Pre-Treatment With Dopamine on Survival After Heart Transplantation: A Cohort Study of Heart Transplant Recipients Nested in a Randomized Controlled Multicenter Trial

Benck U, Hoeger S, Brinkkoetter PT, et al (Univ Med Centre Mannheim, Germany; Univ of Cologne, Germany; et al) J Am Coll Cardiol 58:1768-1777, 2011^§

Abstract

Objectives

We determined the outcome of cardiac allografts from multiorgan donors enrolled in a randomized trial of donor pre-treatment with dopamine.

Background

Treatment of the brain-dead donor with low-dose dopamine improves immediate graft function after kidney transplantation.

Methods

A cohort study of 93 heart transplants from 21 European centers was undertaken between March 2004 and August 2007. We assessed post-transplant left ventricular function (LVF), requirement of a left ventricular assist device (LVAD) or biventricular assist device (BVAD), need for hemofiltration, acute rejection, and survival of recipients of a dopamine-treated versus untreated graft.

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