Anesthesia Techniques and Monitors

Meta-analysis of desflurane and propofol average times and variability in times to extubation and following commands

Wachtel RE, Dexter F, Epstein RH, et al (Univ of Iowa; Jefferson Med College, Philadelphia, PA) Can J Anaesth 58:714-724, 2011^§

Abstract

Purpose

We performed a meta-analysis to compare the operating room recovery time of desflurane with that of propofol.

Methods

Studies were included in which a) humans were assigned randomly to propofol or desflurane groups without other differences between groups (e.g., induction drugs) and b) mean and standard deviation were reported for extubation time and/or time to follow commands. Since there was heterogeneity of variance between treatment groups in the log-scale (i.e., unequal coefficients of variation of observations in the time scale), generalized pivotal methods for the lognormal distribution were used as inputs of the random effects meta-analyses.

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