Studies of Outcomes, Risks, Costs, and Benefits

Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial

Jenkins DJ, Jones PJ, Lamarche B, et al (St Michael’s Hosp, Toronto, Ontario, Canada; Univ of Toronto, Ontario, Canada; Laval Univ, Quebec City, Canada; et al) JAMA 306:831-839, 2011^§

Abstract

Context

Combining foods with recognized cholesterol-lowering properties (dietary portfolio) has proven highly effective in lowering serum cholesterol under metabolically controlled conditions.

Objective

To assess the effect of a dietary portfolio administered at 2 levels of intensity on percentage change in low-density lipoprotein cholesterol (LDL-C) among participants following self-selected diets.

Design, Setting, and Participants

A parallel-design study of 351 participants with hyperlipidemia from 4 participating academic centers across Canada (Quebec City, Toronto, Winnipeg, and Vancouver) randomized between June 25, 2007, and February 19, 2009, to 1 of 3 treatments lasting 6 months.

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