Pharmacology. Methocarbamol is a centrally acting muscle relaxant. It does not directly relax skeletal muscle and does not depress neuromuscular transmission or muscle excitability; muscle relaxation is probably related to its sedative effects. After intravenous administration, the onset of action is nearly immediate. Elimination occurs by hepatic metabolism, with a serum half-life of 0.9–2.2 hours.

Indications

1. 
   

   Control of painful muscle spasm caused by black widow spider envenomation (See Spiders). Methocarbamol should be used as an adjunct to other medications (eg, morphine, diazepam) that are considered more effective.

   
   
2. 
   

   Management of muscle spasm caused by mild tetanus (See Tetanus) or strychnine (See Strychnine) poisoning.

Contraindications

1. 
   

   Known hypersensitivity to the drug.

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