Bolus
Infusion
Midazolam 0.5–2 mg (titrated up to 0.07 mg/kg)
Remifentanil 0.05–0.0625 μg/kg/min
Fentanyl 0.25–0.5 μg/kg
Propofol 1.5–3 mg/kg/h (25–50 μg/kg/min)
Ketamine 0.1–0.2 mg/kg
Dexmedetomidine 0.2–0.7 μg/kg/h
Table 17.2
Suggested anesthetic doses for nerve block
Nerve block and drug | Bolus dose | Infusion | Useful adjunct |
---|---|---|---|
Spinal | |||
Isobaric bupivacaine | 5–15 mg | N/A | Epinephrine 0.3 mg |
Morphine 0.1 mg | |||
Fentanyl 10–25 μg | |||
Epidural | |||
Bupivacaine | 0.5 %, 5–10 mL | 0.125 %, 5–10 mL/h | Morphine 0.05–0.1 mg/mL |
Fentanyl 1–2 μg/mL | |||
Levobupivacaine | 0.5 %, 5–10 mL | 0.125 %, 5–10 mL/h | Morphine 0.05–1 mg/mL |
Fentanyl 1–2 μg/mL | |||
Ropivacaine | 0.5 %, 5–10 mL | 0.2 %, 5–10 mL/h | Morphine 0.05–1 mg/mL |
Fentanyl 1-2 μg/mL | |||
Peripheral | |||
Bupivacaine | 0.5 %, 20 mL | 0.2 %, 5–10 mL | N/A |
Levobupivacaine | 0.5 %, 20 mL | 0.2 %, 5–10 mL | N/A |
Ropivacaine | 0.5 %, 20 mL | 0.2 %, 5–10 mL | N/A |
References
1.
Roy RC. Choosing general versus regional anesthesia for the elderly. Anesthesiol Clin North America. 2000;18:91–104, vii.
2.
Gustafson Y, Berggren D, Brannstrom B, Bucht G, Norberg A, Hansson LI, Winblad B. Acute confusional states in elderly patients treated for femoral neck fracture. J Am Geriatr Soc. 1988;36:525–30.PubMed
4.
Hole A, Terjesen T, Breivik H. Epidural versus general anaesthesia for total hip arthroplasty in elderly patients. Acta Anaesthesiol Scand. 1980;24:279–87.PubMed
5.
Papaioannou A, Fraidakis O, Michaloudis D, Balalis C, Askitopoulou H. The impact of the type of anaesthesia on cognitive status and delirium during the first postoperative days in elderly patients. Eur J Anaesthesiol. 2005;22:492–9.PubMed
6.
Haan J, van Kleef JW, Bloem BR, Zwartendijk J, Lanser JB, Brand R, van der Does I, Krul EJ, Elshove HM, Moll AC. Cognitive function after spinal or general anesthesia for transurethral prostatectomy in elderly men. J Am Geriatr Soc. 1991;39:596–600.PubMed
7.
Fong HK, Sands LP, Leung JM. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006;102:1255–66.PubMed
8.
Sprung J, Gajic O, Warner DO. Review article: age related alterations in respiratory function—anesthetic considerations. Can J Anaesth. 2006;53:1244–57.PubMed
9.
Halaszynski TM. Pain management in the elderly and cognitively impaired patient: the role of regional anesthesia and analgesia. Curr Opin Anaesthesiol. 2009;22:594–9.PubMed
10.
Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siersma VD, Vila P, Jolles J, Papaioannou A, Abildstrom H, Silverstein JH, Bonal JA, Raeder J, Nielsen IK, Korttila K, Munoz L, Dodds C, Hanning CD, Moller JT. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand. 2003;47:260–6.PubMed
11.
Gulur P, Nishimori M, Ballantyne JC. Regional anaesthesia versus general anaesthesia, morbidity and mortality. Best Pract Res Clin Anaesthesiol. 2006;20:249–63.PubMed
12.
Chung F, Meier R, Lautenschlager E, Carmichael FJ, Chung A. General or spinal anesthesia: which is better in the elderly? Anesthesiology. 1987;67:422–7.PubMed
13.
Cohendy R, Brougere A, Cuvillon P. Anaesthesia in the older patient. Curr Opin Clin Nutr Metab Care. 2005;8:17–21.PubMed
14.
Modig J, Borg T, Karlstrom G, Maripuu E, Sahlstedt B. Thromboembolism after total hip replacement: role of epidural and general anesthesia. Anesth Analg. 1983;62:174–80.PubMed
15.
Modig J, Maripuu E, Sahlstedt B. Thromboembolism after total hip replacement: a prospective investigation of 94 patients with emphasis of the efficacy of lumbar epidural anesthesia in prophylaxis. Reg Anesth. 1986;11:72–9.
16.
Keith I. Anaesthesia and blood loss in total hip replacement. Anaesthesia. 1977;32:444–50.PubMed
17.
Sorenson RM, Pace NL. Anesthetic techniques during surgical repair of femoral neck fractures. A meta-analysis. Anesthesiology. 1992;77:1095–104.PubMed
18.
Matot I, Oppenheim-Eden A, Ratrot R, Baranova J, Davidson E, Eylon S, Peyser A, Liebergall M. Preoperative cardiac events in elderly patients with hip fracture randomized to epidural or conventional analgesia. Anesthesiology. 2003;98:156–63.PubMed
19.
Yeager MP, Glass DD, Neff RK, Brinck-Johnsen T. Epidural anesthesia and analgesia in high-risk surgical patients. Anesthesiology. 1987;66:729–36.PubMed
20.
Garcia Collada JC, Pereda Marin RM, Miralles Serrano EM, Garrote Martinez AI, Pacheco Lopez JF. Axillary brachial plexus block in an elderly patient with a previous 48-h standing acute myocardial infarct. Acta Anaesthesiol Scand. 2004;48:387–8.PubMed
21.
Bode Jr RH, Lewis KP, Zarich SW, Pierce ET, Roberts M, Kowalchuk GJ, Satwicz PR, Gibbons GW, Hunter JA, Espanola CC. Cardiac outcome after peripheral vascular surgery. Comparison of general and regional anesthesia. Anesthesiology. 1996;84:3–13.PubMed
22.
Breen P, Park KW. General anesthesia versus regional anesthesia. Int Anesthesiol Clin. 2002;40:61–71.PubMed
23.
Nielsen KC, Steele SM. Outcome after regional anaesthesia in the ambulatory setting—is it really worth it? Best Pract Res Clin Anaesthesiol. 2002;16:145–57.PubMed
24.
Brull SJ. Choice of regional versus general anesthesia. In: McLeskey CH, editor. Geriatric anesthesiology. Baltimore: Williams & Wilkins; 1997. p. 361–6.
25.
Kanto J, Maenpaa M, Mantyla R, Sellman R, Valovirta E. Effect of age on the pharmacokinetics of diazepam given in conjunction with spinal anesthesia. Anesthesiology. 1979;51:154–9.PubMed
26.
Arisaka H, Sakuraba S, Takeda J. Effects of spinal anesthesia on the electroencephalogram in the elderly. Acta Anaesthesiol Belg. 2008;59:15–7.PubMed
27.
Kurup V, Ramani R, Atanassoff PG. Sedation after spinal anesthesia in elderly patients: a preliminary observational study with the PSA-4000. Can J Anaesth. 2004;51:562–5.PubMed
28.
Sieber FE, Gottshalk A, Zakriya KJ, Mears SC, Lee H. General anesthesia occurs frequently in elderly patients during propofol-based sedation and spinal anesthesia. J Clin Anesth. 2010;22:179–83.PubMed
29.
Jacobs JR, Reves JG, Marty J, White WD, Bai SA, Smith LR. Aging increases pharmacodynamic sensitivity to the hypnotic effects of midazolam. Anesth Analg. 1995;80:143–8.PubMed
30.
Maitre PO, Buhrer M, Thomson D, Stanski DR. A three-step approach combining Bayesian regression and NONMEM population analysis: application to midazolam. J Pharmacokinet Biopharm. 1991;19:377–84.PubMed
31.
Bell GD, Spickett GP, Reeve PA, Morden A, Logan RF. Intravenous midazolam for upper gastrointestinal endoscopy: a study of 800 consecutive cases relating dose to age and sex of patient. Br J Clin Pharmacol. 1987;23:241–3.PubMedPubMedCentral
32.
CPS: compendium of pharmaceuticals and specialties. 38th ed. Ottawa: Canadian Pharmacists Association; 2003. p. 1003–8.
33.
White PF, Boure B. Outpatient anesthesia for geriatric patients. In: McLeskey CH, editor. Geriatric anesthesiology. Baltimore: Williams & Wilkins; 1997. p. 441–57.
34.
Munoz HR, Dagnino JA, Rufs JA, Bugedo GJ. Benzodiazepine premedication causes hypoxemia during spinal anesthesia in geriatric patients. Reg Anesth. 1992;17:139–42.PubMed
35.
Fernandez-Galinski D, Rue M, Moral V, Castells C, Puig MM. Spinal anesthesia with bupivacaine and fentanyl in geriatric patients. Anesth Analg. 1996;83:537–41.PubMed
36.
Pavlin DJ, Coda B, Shen DD, Tschanz J, Nguyen Q, Schaffer R, Donaldson G, Jacobson RC, Chapman CR. Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers. Anesthesiology. 1996;84:23–37.PubMed
37.
Vinik HR, Bradley Jr EL, Kissin I. Triple anesthetic combination: propofol-midazolam-alfentanil. Anesth Analg. 1994;78:354–8.PubMed
38.
McHardy FE, Fortier J, Chung F, Krishnathas A, Marshall SI. A comparison of midazolam, alfentanil and propofol for sedation in outpatient intraocular surgery. Can J Anaesth. 2000;47:211–4.PubMed
39.
Rewari V, Madan R, Kaul HL, Kumar L. Remifentanil and propofol sedation for retrobulbar nerve block. Anaesth Intensive Care. 2002;30:433–7.PubMed
40.
Aydin ON, Ugur B, Kir E, Ozkan SB. Effect of single-dose fentanyl on the cardiorespiratory system in elderly patients undergoing cataract surgery. J Clin Anesth. 2004;16:98–103.PubMed
41.
Minto CF, Schnider TW, Egan TD, Youngs E, Lemmens HJ, Gambus PL, Billard V, Hoke JF, Moore KH, Hermann DJ, Muir KT, Mandema JW, Shafer SL. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology. 1997;86:10–23.PubMed
42.
Krenn H, Deusch E, Jellinek H, Oczenski W, Fitzgerald RD. Remifentanil or propofol for sedation during carotid endarterectomy under cervical plexus block. Br J Anaesth. 2002;89:637–40.PubMed
43.
Mingus ML, Monk TG, Gold MI, Jenkins W, Roland C. Remifentanil versus propofol as adjuncts to regional anesthesia. Remifentanil 3010 Study Group. J Clin Anesth. 1998;10:46–53.PubMed
44.
Marrocco-Trischitta MM, Bandiera G, Camilli S, Stillo F, Cirielli C, Guerrini P. Remifentanil conscious sedation during regional anaesthesia for carotid endarterectomy: rationale and safety. Eur J Vasc Endovasc Surg. 2001;22:405–9.PubMed
45.
Paris A, Tonner PH. Dexmedetomidine in anaesthesia. Curr Opin Anaesthesiol. 2005;18:412–8.PubMed
46.
Kunisawa T, Hanada S, Kurosawa A, Suzuki A, Takahata O, Iwasaki H. Dexmedetomidine was safely used for sedation during spinal anesthesia in a very elderly patient. J Anesth. 2010;24:938–41.PubMed
47.
Hong JY, Kim WO, Yoon Y, Choi Y, Kim SH, Kil HK. Effects of intravenous dexmedetomidine on low-dose bupivacaine spinal anaesthesia in elderly patients. Acta Anaesthesiol Scand. 2012;56:382–7.PubMed
49.
Sadove MS, Shulman M, Hatano S, Fevold N. Analgesic effects of ketamine administered in subdissociative doses. Anesth Analg. 1971;50:452–7.PubMed
50.
Idvall J, Ahlgren I, Aronsen KR, Stenberg P. Ketamine infusions: pharmacokinetics and clinical effects. Br J Anaesth. 1979;51:1167–73.PubMed
51.
Frey K, Sukhani R, Pawlowski J, Pappas AL, Mikat-Stevens M, Slogoff S. Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles. Anesth Analg. 1999;89:317–21.PubMed
52.
Rosenberg MK, Raymond C, Bridge PD. Comparison of midazolam/ketamine with methohexital for sedation during peribulbar block. Anesth Analg. 1995;81:173–4.PubMed
53.
Kirkpatrick T, Cockshott ID, Douglas EJ, Nimmo WS. Pharmacokinetics of propofol (diprivan) in elderly patients. Br J Anaesth. 1988;60:146–50.PubMed
54.
Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, Youngs EJ. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998;88:1170–82.PubMed
55.
Vuyk J, Oostwouder CJ, Vletter AA, Burm AG, Bovill JG. Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion. Br J Anaesth. 2001;86:183–8.PubMed
56.
Gragasin FS, Bourque SL, Davidge ST. Vascular aging and hemodynamic stability in the intraoperative period. Front Physiol. 2012;3:74.PubMedPubMedCentral