Leukocyte Depletion of Transfused Blood to Reduce Perioperative Mortality


Study

Setting

No. of patients

Blood products

End points

Results (%)

p

van de Watering [5]

Cardiac surgery

914

BCD-RBC vs. LR (pre-storage) vs. LR (poststorage)

60-day mortality

7.8 vs. 3.6 vs. 3.3

0.015

Bilgin [6]

Cardiac surgery

474

BCD-RBC vs. LR (pre-storage)

Hospital mortality

10.1 vs. 5.5

0.05
    
90-day mortality

12.7 vs. 8.4

n.s.

Connery [7]

Cardiac surgery

98

BCD-RBC vs. LR

30-day mortality

3.2 vs. 2.6

n.s.

Wallis [8]

Cardiac surgery

597

BCD or plasma-reduced RBC vs. WBC-filtered

90-day mortality

2.9 vs. 2.5 vs. 0.5

n.s.

Bracey [7]

Cardiac surgery

443

BCD-RBC vs. LR (pre-storage)

Hospital mortality

7.5 vs. 5.9

n.s.

Boshkov [10]

Cardiac surgery

1,227

BCD-RBC vs. LR

60-day mortality

9.7 vs. 4.9
 
Jensen [13]

Colorectal surgery

586

BCD-RBC vs. LR (pre-storage)

Hospital mortality

2.8 vs. 3.4

n.s.

Titlestad [15]

Colorectal surgery

279

BCD-RBC vs. LR (pre-storage)

30-day mortality

8.5 vs. 3.6

n.s.

Skamberg [15]

Colorectal cancer surgery

642

BCD-RBC vs. LR

99-month mortality

49.7 vs. 52.5

n.s.

Dzik [16]

Medical/major surgery

2,780

RBC vs. LR (pre-storage)

Hospital mortality

8.5 vs. 9.0

n.s.

Van Hilten [17]

Gastrointestinal and aortic aneurysm surgery

1,051

BCD-RBC vs. LR (pre-storage)

Hospital mortality

8.4 vs. 10.3

n.s.

Nielsen [18]

Burns/trauma

24

BCD-RBC vs. LR (pre-storage)

Hospital mortality

33.3 vs. 16.6

n.s.


ABT allogenic blood transfusion, TRIM transfusion-related immunomodulation, LR leukoreduction, RCT randomized controlled trial, RBC red blood cells, BCD buffy coat depleted, MODS multi-organ dysfunction syndrome, CABG coronary artery bypass grafting, CPB cardiopulmonary bypass, SIRS systemic inflammatory response syndrome, CARS compensatory anti-inflammatory response syndrome




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Apr 6, 2017 | Posted by in CRITICAL CARE | Comments Off on Leukocyte Depletion of Transfused Blood to Reduce Perioperative Mortality

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