Studies of Outcomes, Risks, Costs, and Benefits

Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment

Bayer-Carter JL, Green PS, Montine TJ, et al (Veterans Affairs Puget Sound Health Care System, Seattle, WA) Arch Neurol 68:743-752, 2011^§

Abstract

Objective

To compare the effects of a 4-week high-saturated fat/high-glycemic index (HIGH) diet with a low-saturated fat/low-glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI).

Design

Randomized controlled trial.

Setting

Veterans Affairs Medical Center clinical research unit.

Participants

Forty-nine older adults (20 healthy adults with a mean [SD] age of 69.3 [7.4] years and 29 adults with aMCI with a mean [SD] age of 67.6 [6.8] years).

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