Hyperthermia












Spontaneous clonus
Inducible clonus plus agitation or diaphoresis
Ocular clonus plus agitation or diaphoresis
Tremor plus hyperreflexia
Hypertonia plus temperature above 38U+02DAC plus ocular clonus or inducible clonus




Table 64.2. Serotonin syndrome (SS) vs. neuroleptic malignant syndrome (NMS)




























SS NMS
Onset 24 hours Days to weeks
Precipitating medications Serotonergic agents (e.g., SSRIs, MAOIs, meperidine, linezolid, psychoactive drugs of abuse) Antipsychotics (e.g., phenothiazines, butyrophenones, thioxanthines)
Mechanism of action Stimulation of serotonin receptors Dopamine blockade
Neuromuscular abnormality Clonus Rigidity
Specific treatment Cyproheptadine Bromocriptine





MAOI, monoamine oxidase inhibitor. SSRI, selective serotonin re-uptake inhibitor.

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Feb 17, 2017 | Posted by in CRITICAL CARE | Comments Off on Hyperthermia

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