Studies of Outcomes, Risks, Costs, and Benefits

Public health importance of triggers of myocardial infarction: a comparative risk assessment

Nawrot TS, Perez L, Künzli N, et al (Hasselt Univ, Diepenbeek, Belgium; Univ of Basel, Switzerland) Lancet 377:732-740, 2011^§

Abstract

Background

Acute myocardial infarction is triggered by various factors, such as physical exertion, stressful events, heavy meals, or increases in air pollution. However, the importance and relevance of each trigger are uncertain. We compared triggers of myocardial infarction at an individual and population level.

Methods

We searched PubMed and the Web of Science citation databases to identify studies of triggers of non-fatal myocardial infarction to calculate population attributable fractions (PAF). When feasible, we did a meta-regression analysis for studies of the same trigger.

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