Drugs
Cost IV
Cost per os
Cost/day IV
Cost/day per os
Paracetamol (1 g)
$1.12
$0.03
$4.47
$0.11
Ketoprofen (100 mg)
$0.98
$0.21
$2.94
$0.41
Nefopam
$0.62
$0.62
$3.73
$3.73
Ketamine 50 mg (8 mg/h)
$1.55
($5.94)
Gabapentin (300 mg)
$0.12
$0.37
Ketamine
At low doses, ketamine, a non-competitive antagonist (on non-methyl-D-aspartate, NMDA), is able to limit the awareness of the central nervous system in painful animals, in healthy volunteers exposed to various models of pain and in postoperative patients. In fact, a study reported a significant decrease of the postoperative pain level and better functional recovery in patients undergoing TKA after low dose of ketamine intravenously (Adam et al. 2005). It also allows a reduction in morphine consumption after THA (Remérand et al. 2009). Ketamine is more effective with a preoperative bolus (0.1–0.5 mg/kg) followed by a continuous infusion during 48 h (2 μg/kg/min or above 5–12 mg/h). Ketamine decreases the postoperative pain in limiting both postoperative hyperalgesia after the surgical trauma and intraoperative use of high doses of opioids. This limits the use of analgesics, reduces morphine tolerance and improves the overall quality of analgesia in postoperative period (Bell et al. 2005). The cost of 50 mg of ketamine is above 1.5 dollars.
Gabapentin
Before surgery, gabapentin not only reduces morphine consumption but also the postoperative pain at rest and in dynamic conditions (Clarke et al. 2009b; Dahl et al. 2004; Hurley et al. 2006). It also improves functional recovery after orthopaedic surgery (Ménigaux et al. 2005) and prevents pruritus induced by intrathecal morphine in patients undergoing lower extremity surgery under spinal anaesthesia (Sheen et al. 2008). It’s mainly due to a presynaptic blockage of calcium channel voltages dependent resulting in an anti-hyperalgesic effect. However, recent studies have shown that the effectiveness of gabapentin given preoperatively in THA (Clarke et al. 2009a) or in TKA (Paul et al. 2013) may not be as high as initially described. Currently French recommendations concerning postoperative analgesia propose to use gabapentin premedication without exceeding one daily dose of 800 mg to avoid side effects like sedation or dizziness. The cost of 300 mg gabapentin per os is $0.13.
Intravenous Lidocaine
It has been shown that the use of low doses of intravenous lidocaine before and after THA did not improve postoperative analgesia (Martin et al. 2008). Lidocaine is probably recommended for analgesia in abdominal surgery, but not in orthopaedic surgery.
12.3.1.2 Opioid Analgesia
Prosthetic joint replacement surgery is considered like a moderate to severe painful surgery, and the use of opioids called « strong » (level III of WHO) is recommended, including the use of controlled analgesia with an opioid pump device. The cost of this system is about $4,917 (amortized over 5 years with $1,530 per year and used about 260 days per year with finally an approximate daily cost of $5.9). Annual maintenance is approximately $546 and disposables such as injectable morphine are $0.9 (100 mg/10 ml), a charging pump ($18) and an adapter ($4). All disposables bring the daily cost of these morphine pumps at $29. It must be added to the nurse working time which is estimated around $16 for the installation. In conclusion the total cost for a morphine pump is about $45. The oral treatment can be provided by morphine sulphate with a total cost of $0.14 daily for 10 mg.
12.3.2 Intrathecal and Epidural Analgesia
According to the French recommendations in 2007 (Fuzier et al. 2007), epidural analgesia provides the same analgesia than peripheral nerve blocks but a better analgesia at rest and especially during mobilization than analgesia with drugs alone. However, epidural analgesia is not without risks or side effects, and the risk to benefit ratio is clearly in favour of peripheral blocks for the management of post-arthroplasty analgesia. The central blocks can induce arterial hypotension, acute retention of urine, infectious complications and headaches. They have a small benefit in terms of morbidity and mortality and a low profitability on convalescence: therefore, epidural analgesia is not indicated after lower limb arthroplasty (Fletcher and Jayr 2009). However, indications should be discussed in each case.
The cost of epidural analgesia over a period of 72 h is as follows: aseptic surgical equipment (sterile gloves, coat, operative field and compresses) ($5.1), analgesia catheter Perifix® ($11.3), tools for fixing the catheter to the skin ($2.6), syringe of 20 ml ($0.13), a vial of 20 ml of ropivacaine 0.2 % ($1.8) and a vial of 400 mg in 200 ml of ropivacaine ($9.8/ 24 h, $29.5/ 72 h): the cost of epidural analgesia for 72 h is estimated at $50, plus the cost of nursing time. That brings the final cost at a total of $16.8 per day.
Spinal anaesthesia may be used for arthroplasty surgery of the lower limb as well as to start postoperative analgesia. Indeed the use of adjuvants, such as clonidine, or liposoluble opioids can potentiate the action of local anaesthetics. The postoperative analgesic effect does not exceed 12–14 h, and the use of high doses quickly exposes to many side effects (sedation, pruritus, nausea and vomiting, acute urinary retention, hypotension). Despite a low cost, estimated at $10.5, the profitability of spinal anaesthesia in terms of postoperative analgesia seems minimal because of many side effects and a short analgesia.
12.3.3 Peripheral Analgesia
12.3.3.1 Blocks and Perineural Catheters Devices
Indications, Feasibility and Cost
According to French expert recommendations (Fuzier et al. 2007), it is recommended to use peripheral blocks for postoperative analgesia of arthroplasty surgery compared with epidural analgesia. The benefit of analgesia with peripheral blocks is also true with intravenous patient-controlled analgesia with morphine pump. Indeed perineural blocks minimize the sympathetic response to surgery, reduced postoperative pain especially during mobilization, improve analgesia during the postoperative period and increase patient’s satisfaction.
The cost of a single ultrasound-guided peripheral nerve block injection is estimated at $20.85 including the needle, aseptic equipment, injection equipment, local anaesthetic and a set of protection of the ultrasound probe. The cost of this technique of analgesia with continuous injection of ropivacaine for 72 h is estimated at $77 (Table 12.2).
Table 12.2
Cost of peripheral analgesia (dollars)
Ultrasound-guided nerve block | Cost of treatment | Cost of treatment per day |
---|---|---|
Single-shot injection | $20.85 | $20.85 |
Perineural catheter (72 h) | $77.72 | $25.91 |
Today, it’s not mandatory to use ultrasound for a peripheral nerve block (single injection or catheterization). Indeed, the evaluation of the cost-effectiveness of locoregional analgesia ultrasound guided versus neurostimulation has not yet been evaluated. The cost of an ultrasound is around $54 630 plus the prices of disposables (ultrasound gel, sterile protection of ultrasound probes, plus the cost of maintenance), while a neurostimulator costs about $1,161. Up to now, the superiority of ultrasound compared with neurostimulation on the success of locoregional anaesthesia has not been demonstrated. There is however several advantages for ultrasound: a direct visualization of the needle and of the surrounding tissue and the dissemination of local anaesthetic. Ultrasound helps to decrease time required to perform the nerve blocks, the number of needle’s redirection and the number of vascular punctures and decrease the setting time of nerve blocks (Casati et al. 2007; Domingo-Triadó et al. 2007; Marhofer et al. 1998; Soeding et al. 2005). Ultrasound also allows a better understanding of the anatomical variations. There is also a decrease of complications due to systemic toxicity of local anaesthetic (Barrington and Kluger 2013). It also improves patient’s satisfaction by reducing the discomfort of the nerve research by neurostimulation (Koscielniak-Nielsen et al. 2002) and by decreasing pain in trauma patient (Casati et al. 2007; Soeding et al. 2005). The impact on the risk of postoperative neuropathy is less clear, but a trend in favour of ultrasonographic techniques has been outlined (Orebaugh et al. 2012). Thus, the cost of an ultrasound remains the main limitation compared to standard neurostimulation techniques. However, a study published in 2004 reported the same cost for an infraclavicular block under ultrasound and neurostimulation (the introduction of a catheter costs only 13.90 dollars more with ultrasound) (Sandhu et al. 2004). Another study published in 2012 compared the cost- effectiveness of the analgesia produced by an ultrasound-guided popliteal sciatic catheter inserted with the same block by neurostimulation approach. The use of ultrasound is associated with a higher probability of success and reduced the costs about 84.7 % (Ehlers et al. 2012).
Hip Arthroplasty
For postoperative analgesia, a femoral nerve block with a single injection is recommended (Comité douleur-anesthésie locorégionale et le comité des référentiels de la Sfar 2008b).
Knee Arthroplasty
The debate is over: the French guidelines recommend the use of a femoral perineural catheter, probably associated with a single-injection sciatic nerve block (Comité douleur-anesthésie locorégionale et le comité des référentiels de la Sfar 2008b; Eledjam and viel 2013), while an European working group (PROSPECT Group) recommend neither a single injection nor a continuous infusion femoral nerve block because of too much heterogeneity among studies (Fischer et al. 2008).
If the implementation of a femoral nerve block, at least as a single injection, seems obvious to improve the management of acute and chronic pain after TKA, the effect of a sciatic block has to be demonstrated. Indeed, Wegener et al. (2013) did not find any significant difference in terms of functional recovery, and acute and chronic pain in patients who underwent TKA with a continuous femoral block alone or combined with a single or continuous injection sciatic nerve block. Sinha et al. (2012) found an improvement of postoperative acute pain in patients with a femoral catheter associated with a sciatic block or elective tibial block.
Thus, peripheral nerve blocks after arthroplasty surgery improve management of acute and chronic pain (Liu et al. 2012), reduce postoperative morphine consumption and improve patient’s satisfaction (Fischer et al. 2008). However, the locoregional anaesthesia leads to postoperative quadriceps paresis whatever the concentration and volume of the local anaesthetic (Bauer et al. 2012). It may alter the initial functional recovery and increase the number of falls (Johnson et al. 2013).
12.3.3.2 Infiltration of Local Anaesthetic
In 2011, Kehlet performed a review of literature about analgesic infiltration after hip and knee arthroplasty (Kehlet and Andersen 2011).
This approach was first described by Bianconi et al. in 2003 (Bianconi et al. 2003): patients undergoing THA or TKA with continuous infiltration of ropivacaine in scar had better pain control than those receiving only systemic analgesia. Kerr and Kohan, in a case study of 325 patients, reported an excellent pain control after systematic periarticular infiltration with a mixture of ropivacaine associated with ketorolac and adrenaline (Kerr and Kohan 2008). Rostlund and Kehlet also described an excellent analgesia after infiltration of high doses of long-acting local anaesthetic: there was no motor block, a low morbidity and a length of hospital stay reduced (Röstlund and Kehlet 2007).
Despite positive results in many studies, the apparent simplicity and safety of the technique, Kehlet points to several methodological errors and a lack of comparison with other analgesic techniques such as peripheral nerve blocks (Kehlet and Andersen 2011). In conclusion, there is little evidence to support the use of analgesic infiltration after THA. On the contrary after TKA, the scientific data support the use of intraoperative infiltration of long-acting local anaesthetic, but not the use of a catheter for continuous infiltration of the scar. Few current data support the use of NSAIDs or adrenaline in mixtures of analgesic infiltration, although a recent study advocates the use of ketorolac (Andersen et al. 2013b).
A recent meta-analysis of Keijsers et al. (2013) concludes that infiltration of local anaesthetic improves postoperative analgesia and reduces morphine consumption on the first postoperative day after a TKA when compared to placebo. However, in a review of Fowler and Christellis (2013), the authors report that the equivalence in terms of analgesia and functional outcome is not clear between infiltration and peripheral nerve blocks. This is confirmed by the study of Carli et al. (2010): a better management of pain and improved functional recovery initially and at 6 weeks with continuous perineural femoral techniques. Otherwise many studies describe earlier and more effective ambulation when infiltration is performed as compared to a continuous femoral block (Chaumeron et al. 2013; Perlas et al. 2013; Rivière et al. 2012). A local analgesic infiltration reduces pain after TKA in the same manner as peripheral nerve block, but without motor block. However, volumes and therefore doses of local anaesthetic are more important than with locoregional anaesthesia exposing them to a potential systemic toxicity.
In addition, the duration and effectiveness of analgesia by infiltration remain insufficient compared with a continuous femoral nerve block. The latest studies report states that the combination of a catheter on the adductor feeder (continuous block of the saphenous nerve) and a local periarticular infiltration provides equivalent analgesia to a continuous femoral nerve block (Andersen et al. 2013a). It’s associated with earlier ambulation and a less functional impairment of quadriceps (Jæger et al. 2013b; Jaeger et al. 2013a; Kwofie et al. 2013). However, other studies are needed before recommending this technique.
Moreover, it has also been proposed to use a liposomal bupivacaine to extend the analgesic effect of local anaesthetic. An animal study published in 2012 (Ohri et al. 2012) reported a duration of sensory block of about 40 h and a motor block about 36 h after sciatic nerve block. Thus, the use of the liposomal bupivacaine would improve analgesia by extending the duration of sensory block. If the duration of motor block is increased as well, it would compromise the initial functional recovery. It would be interesting to use this liposomal bupivacaine by infiltration as it has been recently described. However, the cost of around $283 per vial is a main limitation.