Antiepileptic Agents



Chemical Structure 29.1
Gabapentin



A310120_1_En_29_Fig2_HTML.jpg


Chemical Structure 29.2
Phenytoin


A310120_1_En_29_Fig3_HTML.jpg


Chemical Structure 29.3
Carbamazepine


A310120_1_En_29_Fig4_HTML.jpg


Chemical Structure 29.4
Lamotrigine


A310120_1_En_29_Fig5_HTML.jpg


Chemical Structure 29.5
Levetiracetam


A310120_1_En_29_Fig6_HTML.jpg


Chemical Structure 29.6
Topiramate


A310120_1_En_29_Figa_HTML.jpg


Chemical Structure 29.7
Ethosuximide





References



1.

Sirven JI, Noe K, Hoerth M, Drazkowski J. Antieplileptic drugs 2012: recent advances and trends. Mayo Clin Proc. 2012;87(9):879–89.PubMedCentralPubMed


2.

Ochoa JG, Benbadi SR, Riche W, Passaro EA, Talavera F. Antiepileptic drugs. Medscape Reference © 2011 WebMD, LLC [updated 25 Oct 2012]


3.

Perucca E. An introduction to antiepileptic drugs. Epilepsia. 2005;46(Suppl 4):31-37


4.

White HS, Smith MD, Wilcox KS. Mechanisms of action of antiepileptic drugs. Int Rev Neurobiol. 2007;81:85–110.PubMed


5.

Woelfel JA, Cupp M. Comparison of antiepileptic drugs. Pharmacist’s Letter/Prescriber’s Letter, Detail-Document #250707. 2009;25#250707:1–24


6.

Brunton LL, Chabner B, Knollman BC. 12e. Section 2. Neuropharmacology. Chapter 21. Pharmacotherapy of the epilepsies. In: Goodman and Gilman’s pharmacological basis of therapeutics. New York: McGraw-Hill; 2011.


7.

Perucca P, Mula M. Antiepileptic drug effects on mood and behavior: molecular targets. Epilepsy Behav. 2012. Available from: http://​dx.​doi.​org/​10.​1016/​j.​yebeh.​2012.​09.​018.


8.

Hung C, Chen JW. Treatment of post-traumatic epilepsy. Curr Treat Options Neurol. 2012;14:293–306.PubMed


9.

Bialer M, White HS. Key factors in the discovery and development of new antiepileptic drugs. Nat Rev Drug Discov. 2010;9:68–82.PubMed


10.

Cavazos JE, Benbadis SR, Diaz-Arrastia R, Spitz M, Talavera F. Epilepsy and seizures. Medscape Reference ©2011WebMD, LLC [updated 25 Oct 2012]


11.

Wang SP, Mintzer S, Skidmore CT, Zhan T, Stuckert E, Nei M, et al. Seizure recurrence and remission after switching antiepileptic drugs. Epilepsia. 2013;54:187–93.PubMedCentralPubMed


12.

Löscher W, Schmidt D. Perampanel – new promise for refractory epilepsy? Nat Rev Neurol. 2012;13:1–2.


13.

Wasterlain CG, Chen JW. Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs. Epilepsia. 2008;49 Suppl 9:63–73.PubMed


14.

Kleckner NW, Glazewski JC, Chen CC, Moscrip TD. Subtype-selective antagonism of N-Methyl-D-Aspartate receptors by felbamate: insights into the mechanism of action. J Pharmacol Exp Ther. 1999;289(2):886–94.PubMed


15.

Ohno Y, Sofue N, Imaoku T, Morishita E, Kumafuji K, Sasa M, et al. Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy. J Pharmacol Sci. 2012;114:99–105.


16.

Ezogabine FE. A new angle on potassium gates. Epilepsy Curr. 2011;11(3):75–8.


17.

Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, et al. The synaptic vesicle protein SV2 is complexed with an α5-containing laminin on the nerve terminal surface. J Biol Chem. 2000;275(1):451–60.PubMed

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Sep 18, 2016 | Posted by in ANESTHESIA | Comments Off on Antiepileptic Agents

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