PGL, Persistent generalized lymphadenopathy.
Data from US Centers for Disease Control and Prevention. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 1992;41(RR-17):1-19.
World Health Organization Clinical Staging of HIV/AIDS
Acute retroviral syndrome
Clinical stage 1
Persistent generalized lymphadenopathy
Clinical stage 2
Moderate unexplained weight loss (<10% body weight)
Recurrent respiratory infections (sinusitis, tonsillitis, otitis media, pharyngitis)
Recurrent oral ulceration
Papular pruritic eruptions
Clinical stage 3
Severe, unexplained weight loss (>10% body weight)
Unexplained diarrhea lasting >1 month
Unexplained, persistent, constant or intermittent fever >1 month (>37.6° C)
Persistent oral candidiasis
Severe presumed bacterial infections (pneumonia, empyema, pyomyositis, bone and joint infections, meningitis, bacteremia)
Acute necrotizing gingivitis, stomatitis, periodontitis
Unexplained anemia (hemoglobin <8 g/dL)
Neutropenia (<500 cells/mm
3)
Chronic thrombocytopenia (<50,000 cells/mm
3)
Clinical stage 4
All of the AIDS indicator conditions as defined by the CDC classification
andAtypical disseminated leishmaniasis
Symptomatic HIV-associated nephropathy
Symptomatic HIV-associated cardiomyopathy
Reactivation of American trypanosomiasis (meningoencephalitis or myocarditis)
CDC, Centers for Disease Control and Prevention.
Modified from World Health Organization. Case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV related disease in adults and children. Geneva, WHO, 2007. www.who.int/hiv/pub/guidelines/HIVstaging150307.pdf.
Category B: Symptomatic conditions
These conditions must indicate defective cell-mediated immunity caused by HIV infection, or their clinical course and management must be complicated by HIV. Category B conditions include the following:
•
Constitutional symptoms (fever >38.5° C or diarrhea) lasting more than 1 month
•
Candidiasis: oropharyngeal or persistent or recurrent vulvovaginal
•
Pelvic inflammatory disease
•
Moderate or severe cervical dysplasia or carcinoma in situ
•
Idiopathic thrombocytopenic purpura
•
More than two episodes of multidermatomal herpes zoster
Category C: AIDS-defining illnesses
Including bacterial, viral, fungal infections, parasitic infestations, and some cancers
Bacterial:
•
Mycobacterium tuberculosis infection at any site, pulmonary or extrapulmonary
•
Mycobacterium avium complex disease; infection with
Mycobacterium kansasii or other species, disseminated or extrapulmonary
•
Mycobacterium, any species disseminated or extrapulmonary
•
Bacterial pneumonia, recurrent (>2 episodes in 12 months)
•
Nontyphoid
Salmonella septicemia, recurrent
Viral:
•
Cytomegalovirus disease (other than liver, spleen, or nodes) and retinitis with vision loss
•
Herpes simplex virus (chronic ulcer persisting >1 month, bronchitis, pneumonitis, esophagitis)
•
Progressive multifocal leukoencephalopathy
Fungal:
•
Candidiasis of the esophagus, bronchi, trachea, or lungs
•
Coccidioidomycosis, disseminated or extrapulmonary
•
Cryptococcosis, extrapulmonary
•
Histoplasmosis, disseminated or extrapulmonary
•
Isosporiasis, chronic intestinal (persisting for >1 month)
•
Pneumonia, recurrent (
Pneumocystis jiroveci)
